Evidence map›Paper›PMID 36304109›Full record

ArticleiScience2022

A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing.

Roi Isaac, Yaron Vinik, Martin Mikl, Shani Nadav-Eliyahu, Hadas Shatz-Azoulay, Adi Yaakobi, Natalie DeForest, Amit R Majithia, Nicholas J G Webster, Yaron Shav-Tal and 2 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Roi IsaacDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Yaron VinikDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Martin MiklDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Shani Nadav-EliyahuThe Mina & Everard Goodman Faculty of Life Sciences and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 5290002, Israel.
Hadas Shatz-AzoulayDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Adi YaakobiDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Natalie DeForestDepartment of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Amit R MajithiaDepartment of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Nicholas J G WebsterDepartment of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Yaron Shav-TalThe Mina & Everard Goodman Faculty of Life Sciences and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 5290002, Israel.
Eytan ElhananyDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Yehiel ZickDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Weizmann Institute of Science · ILUniversity of California San Diego · USBar-Ilan University · IL

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
Combining experiments of man and nature to target human insulin resistanceR01DK123422 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Amit Majithia · 2020 to 2026
$2.9M
SRSF3 degradation in liver disease and hepatocellular carcinomaI01BX004848 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI WEBSTER, NICHOLAS J · 2020 to 2025
–
BLR&D Research Career Scientist Award ApplicationIK6BX005224 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI WEBSTER, NICHOLAS J · 2020 to 2025
–
BLRD VA I01 BX004848BLRD VA IK6 BX005224NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK123422NIGMS NIH HHS T32 GM008666
6 · The paper itself

Abstract

The seven-transmembrane superfamily member 3 protein (TM7SF3) is a p53-regulated homeostatic factor that attenuates cellular stress and the unfolded protein response. Here we show that TM7SF3 localizes to nuclear speckles; eukaryotic nuclear bodies enriched in splicing factors. This unexpected location for a

Indexed as

BiochemistryBiological sciencesStructural biology

Identifiers

PMID36304109
PMCPMC9593240
OpenAlexW4301368545

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.