Evidence map›Paper›PMID 36304107›Full record

ArticleiScience2022

Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome.

Amrita Sharma, Michael Cipriano, Lori Ferrins, Stephen L Hajduk, Kojo Mensa-Wilmot

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Amrita SharmaDepartment of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA 30144, USA.
Michael CiprianoDepartment of Biochemistry & Molecular Biology, University of Georgia, Athens, GA 30602, USA.
Lori FerrinsDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
Stephen L HajdukDepartment of Biochemistry & Molecular Biology, University of Georgia, Athens, GA 30602, USA.
Kojo Mensa-WilmotDepartment of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA 30144, USA.
Kennesaw State University · USUniversity of Georgia · USNortheastern University · US

Funding

Optimization and Modes of Action of NEU-4438, a New Anti-trypanosome Lead DrugR01AI124046 · NIAID · NORTHEASTERN UNIVERSITY · PI FERRINS, LORI, MENSA-WILMOT, KOJO A. · 2016 to 2025
$6.0M
Curaxin-137, A New Lead for Anti-Trypanosome Drug Discovery - Resubmission - 1R01AI126311 · NIAID · UNIVERSITY OF GEORGIA · PI HAJDUK, STEPHEN L, POLLASTRI, MICHAEL P · 2017 to 2020
$2.7M
Role of African Trypanosome Extracellular Vesicles in Infection and PathogenesisR01AI125487 · NIAID · UNIVERSITY OF GEORGIA · PI HAJDUK, STEPHEN L · 2017 to 2021
$1.9M
NIAID NIH HHS R01 AI124046NIAID NIH HHS R01 AI125487NIAID NIH HHS R01 AI126311
6 · The paper itself

Abstract

NEU-4438 is a lead for the development of drugs against

Indexed as

Microbiologyomicsparasitologyproteomics

Identifiers

PMID36304107
PMCPMC9593816
OpenAlexW4303444338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.