Evidence map›Paper›PMID 36304021›Full record

ArticleFrontiers in reproductive health2021

Genetic Relationship Between Endometriosis and Melanoma.

Fei Yang, Sally Mortlock, Stuart MacGregor, Mark M Iles, Maria Teresa Landi, Jianxin Shi, Matthew H Law, Grant W Montgomery

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in reproductive health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. The interplay between endometriosis and obesity.Trends in endocrinology and metabolism: TEM · 2025
    Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Fei YangThe Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Sally MortlockThe Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Stuart MacGregorStatistical Genetics Group, Department of Genetics and Computational Biology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Mark M IlesLeeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Matthew H LawStatistical Genetics Group, Department of Genetics and Computational Biology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Grant W MontgomeryThe Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
University of Queensland · AUNational Cancer Institute · USQIMR Berghofer Medical Research Institute · AUQueensland University of Technology · AUUniversity of Leeds · GB

Funding

Genetic Epidermiology of MelanomaR01CA083115 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BISHOP, DAVID TIMOTHY, ELDER, DAVID ERIC · 2001 to 2017
$13.0M
NCI NIH HHS R01 CA083115NHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011I
6 · The paper itself

Abstract

Epidemiological studies have observed that risk of endometriosis is associated with history of cutaneous melanoma and vice versa. Evidence for shared biological mechanisms between the two traits is limited. The aim of this study was to investigate the genetic correlation and causal relationship between endometriosis and melanoma. Summary statistics from genome-wide association meta-analyses (GWAS) for endometriosis and melanoma were used to estimate the genetic correlation between the traits and Mendelian randomization was used to test for a causal association. When using summary statistics from separate female and male melanoma cohorts we identified a significant positive genetic correlation between melanoma in females and endometriosis (

Indexed as

endometriosisgenetic correlationgenetic riskmelanomamendelian randomization

Identifiers

PMID36304021
PMCPMC9580819
OpenAlexW3190130461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.