Evidence map›Paper›PMID 36303919›Full record

ArticleHeliyon2022

The comparison of ketamine-dexmedetomidine (ketadex) and ketamine-propofol (ketofol) for procedural sedation in pediatric patients: A meta-analysis of randomized controlled trials.

Peng-Fei Gao, Shi-Yue Li, Yue Li, Le Zhao, Qiang Luo, Yang Ji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peng-Fei GaoState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Anesthesiology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Shi-Yue LiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Anesthesiology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Yue LiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Anesthesiology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Le ZhaoState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Anesthesiology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Qiang LuoState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Anesthesiology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Yang JiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Anesthesiology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The combination of different agents used for procedural sedation allows a greater range of desirable effects while minimizing side effects. The ketamine-dexmedetomidine combination (ketadex) and ketamine-propofol combination (ketofol) are successful examples. The purpose of this meta-analysis was to compare the safety and efficacy of ketadex with ketofol used for procedural sedation in pediatric patients. Methods: We searched Pubmed, Cochrane Controlled Register of Trials, and Embase from inception to June 2022. Studies were independently evaluated for inclusion criteria and exclusion criteria by two reviewers. Outcome measures for safety comparison were the incidence of hypotension, bradycardia, respiratory depression, nausea, vomiting, and agitation; Outcome measure for efficacy comparison was clinicians' satisfaction. In addition, we compared the recovery time of ketadex and ketofol. Results: Nine studies were included in this meta-analysis. Compared with ketofol, ketadex sedation in pediatric patients had lower risk of respiratory depression (RR: 0.51, 95% CI: 0.34-0.76, Conclusions: Both ketadex and ketofol can provide effective sedation and maintain stable hemodynamics. In consideration of good safety profile in respiratory problems, we suggest ketadex is a better option for procedural sedation in pediatric patients.

Indexed as

KetadexKetamine-dexmedetomidineKetamine-propofolKetofolMeta-analysisPediatricProcedural sedation

Identifiers

PMID36303919
PMCPMC9593188

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.