Evidence map›Paper›PMID 36303911›Full record

ArticleHeliyon2022

Melatonin suppresses the antiviral immune response to EMCV infection through intracellular ATP deprivation caused by mitochondrial fragmentation.

Mariko Kikuchi, Miki Kadena, Haruka Fukamachi, Takashi Takaki, Shohei Matsui, Sumire Hoashi-Takiguchi, Hirobumi Morisaki, Nataša Trtić, Mina Mori, Mie Kurosawa and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Mariko KikuchiDepartment of Oral Microbiology and Immunology, Faculty of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
Miki KadenaDepartment of Special Needs Dentistry, Division of Dentistry for Persons with Disabilities, Faculty of Dentistry, Showa University, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo, 145-8515, Japan.
Haruka FukamachiDepartment of Oral Microbiology and Immunology, Faculty of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
Takashi TakakiDivision of Electron Microscopy, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
Shohei MatsuiDepartment of Oral Microbiology and Immunology, Faculty of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
Sumire Hoashi-TakiguchiDepartment of Oral Microbiology and Immunology, Faculty of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
Hirobumi MorisakiDepartment of Oral Microbiology and Immunology, Faculty of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
Nataša TrtićDepartment of Oral Microbiology and Immunology, Faculty of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
Mina MoriDepartment of Oral Microbiology and Immunology, Faculty of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
Mie KurosawaDepartment of Oral Microbiology and Immunology, Faculty of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
Momoe ItsumiDepartment of Oral Microbiology and Immunology, Faculty of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
Takahiro FunatsuDepartment of Pediatric Dentistry, Faculty of Dentistry, Showa University, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo, 145-8515, Japan.
Atsuo SakuraiDepartment of Pediatric Dentistry, Tokyo Dental College, Tokyo, 101-0061, Japan.
Seikou ShintaniDepartment of Pediatric Dentistry, Tokyo Dental College, Tokyo, 101-0061, Japan.
Hiroki KatoInstitute of Cardiovascular Immunology, University Hospital Bonn, University of Bonn, Bonn, 53105, Germany.
Takashi FujitaLaboratory of Molecular Genetics, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, 606-8507, Japan.
Yasubumi MaruokaDepartment of Special Needs Dentistry, Division of Community-Based Comprehensive Dentistry, Faculty of Dentistry, Showa University, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo, 145-8515, Japan.
Hirotaka KuwataDepartment of Oral Microbiology and Immunology, Faculty of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo 142-8555, Japan.
Showa University · JPTokyo Dental College · JPKyoto University · JPUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melatonin, a sleep hormone derived from the pineal gland, has an anti-inflammatory effect on the immune system in addition to modulating the brain nervous system. Previous studies have shown that melatonin suppresses signaling pathways downstream of multiple pattern recognition receptors on the innate immune cells during pathogen infection, but the specific mechanism of suppression has not been well understood. Using an encephalomyocarditis virus (EMCV) infection model in macrophages, we investigated the effects of melatonin on the antiviral response in innate immunity and found that melatonin attenuated the uptake of viral particles into macrophages. Furthermore, melatonin suppressed cytoskeletal regulation by decreasing ATP production by mitochondria. Finally, in an

Indexed as

Antiviral immunityCytokinesInflammationInnate immunityMelatoninMitochondriaNeuro-immunology

Identifiers

PMID36303911
PMCPMC9593192
OpenAlexW4306834979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.