Evidence map›Paper›PMID 36303880›Full record

ReviewaBIOTECH2021

Amorpha-4,11-diene synthase: a key enzyme in artemisinin biosynthesis and engineering.

Jin Quan Huang, Xin Fang

Abstract readReview
In one paragraph

Review in aBIOTECH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Characterization of high-artemisinin yieldingBiochemistry and biophysics reports · 2026
    Article
  2. Article
  3. Review
  4. Supercritical COBiotechnology notes (Amsterdam, Netherlands) · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jin Quan HuangNational Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology/CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 200032 People's Republic of China.
Xin FangState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204 Yunnan People's Republic of China.ORCID 0000-0002-8561-1518

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amorpha-4,11-diene synthase (ADS) catalyzes the first committed step in the artemisinin biosynthetic pathway, which is the first catalytic reaction enzymatically and genetically characterized in artemisinin biosynthesis. The advent of ADS in

Indexed as

Amorpha-4,11-diene SynthaseArtemisininCatalytic mechanismMetabolic engineeringSynthetic biology

Identifiers

PMID36303880
PMCPMC9590458

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.