Evidence map›Paper›PMID 36303872›Full record

ArticleFrontiers in endocrinology2022

Integrative analysis reveals novel associations between DNA methylation and the serum metabolome of adolescents with type 2 diabetes: A cross-sectional study.

Prasoon Agarwal, Brandy A Wicklow, Allison B Dart, Nikho A Hizon, Elizabeth A C Sellers, Jonathan M McGavock, Charlotte P J Talbot, Mario A Fonseca, Wayne Xu, James R Davie and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Methods in DNA methylation array dataset analysis: A review.Computational and structural biotechnology journal · 2024
    Review
  4. Metaboepigenetic regulation of gene expression in obesity and insulin resistance.Metabolomics : Official journal of the Metabolomic Society · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Prasoon AgarwalDiabetes Research Envisioned and Accomplished in Manitoba (DREAM), Research Theme of the Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Brandy A WicklowDiabetes Research Envisioned and Accomplished in Manitoba (DREAM), Research Theme of the Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Allison B DartDiabetes Research Envisioned and Accomplished in Manitoba (DREAM), Research Theme of the Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Nikho A HizonDiabetes Research Envisioned and Accomplished in Manitoba (DREAM), Research Theme of the Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Elizabeth A C SellersDiabetes Research Envisioned and Accomplished in Manitoba (DREAM), Research Theme of the Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Jonathan M McGavockDiabetes Research Envisioned and Accomplished in Manitoba (DREAM), Research Theme of the Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Charlotte P J TalbotDiabetes Research Envisioned and Accomplished in Manitoba (DREAM), Research Theme of the Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Mario A FonsecaDiabetes Research Envisioned and Accomplished in Manitoba (DREAM), Research Theme of the Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Wayne XuDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
James R DavieDiabetes Research Envisioned and Accomplished in Manitoba (DREAM), Research Theme of the Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Meaghan J JonesDiabetes Research Envisioned and Accomplished in Manitoba (DREAM), Research Theme of the Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Animesh AcharjeeInstitute of Cancer and Genomic Sciences, University of Birmingham, Winnipeg, MB, Canada.
Vernon W DolinskyDiabetes Research Envisioned and Accomplished in Manitoba (DREAM), Research Theme of the Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Rates of type 2 diabetes (T2D) among adolescents are on the rise. Epigenetic changes could be associated with the metabolic alterations in adolescents with T2D. Methods: We performed a cross sectional integrated analysis of DNA methylation data from peripheral blood mononuclear cells with serum metabolomic data from First Nation adolescents with T2D and controls participating in the Improving Renal Complications in Adolescents with type 2 diabetes through Research (iCARE) cohort study, to explore the molecular changes in adolescents with T2D. Results: Our analysis showed that 43 serum metabolites and 36 differentially methylated regions (DMR) were associated with T2D. Several DMRs were located near the transcriptional start site of genes with established roles in metabolic disease and associated with altered serum metabolites (e.g. glucose, leucine, and gamma-glutamylisoleucine). These included the free fatty acid receptor-1 Conclusions: We identified DMRs and metabolites that merit further investigation to determine their significance in controlling gene expression and metabolism which could define T2D risk in adolescents.

Indexed as

Diabetes Mellitus, Type 2AdolescentCohort StudiesCross-Sectional StudiesDNA MethylationHumansLeukocytes, MononuclearMetabolomeDNA methylationintegration of datametabolomicspediatricstype 2 diabetes mellitus

Identifiers

PMID36303872
PMCPMC9593237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.