Evidence map›Paper›PMID 36303811›Full record

ArticleWorld journal of gastrointestinal endoscopy2022

Cronkhite-Canada syndrome: First case report from Egypt and North Africa.

Ahmed Elsayed Alzamzamy, Ashraf Aboubakr, Hussein H Okasha, Abeer Abdellatef, Shaimaa Elkholy, Mahmoudd Wahba, Mohamed Alboraie, Hussein Elsayed, Mohamed O Othman

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmed Elsayed AlzamzamyDepartment of Gastroenterology and Hepatology, Maadi Armed Forces Medical Complex, Military Medical Academy, Cairo 11711, Egypt. dr_zamzamy@hotmail.com.
Ashraf AboubakrDepartment of Gastroenterology and Hepatology, Maadi Armed Forces Medical Complex, Military Medical Academy, Cairo 11711, Egypt.
Hussein H OkashaDepartment of Internal Medicine, Division of Gastroenterology, Hepatology and Endoscopy, Cairo University, Cairo 11311, Egypt.
Abeer AbdellatefDepartment of Internal Medicine, Division of Gastroenterology, Hepatology and Endoscopy, Cairo University, Cairo 11311, Egypt.
Shaimaa ElkholyDepartment of Internal Medicine, Division of Gastroenterology, Hepatology and Endoscopy, Cairo University, Cairo 11311, Egypt.
Mahmoudd WahbaDepartment of Internal Medicine, Division of Gastroenterology, Hepatology and Endoscopy, Cairo University, Cairo 11311, Egypt.
Mohamed AlboraieDepartment of Internal Medicine, Al-Azhar University, Cairo 11311, Egypt.
Hussein ElsayedDepartment of Pathology, Military Medical Academy, Cairo 11711, Egypt.
Mohamed O OthmanDepartment of Internal Medicine, Baylor College of Medicine, Houston, TX 77082, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastrointestinal (GI) polyposis is a rare condition in GI diseases. To date about 500 cases of Cronkhite-Canada syndrome (CCS) have been reported worldwide. CASE SUMMARY: We report a 60-year-old female patient who presented with dyspepsia, abdominal pain, and weight loss of 1-year duration. Her physical examination showed alopecia and onychodystrophy. Upper endoscopy revealed diffuse markedly thickened gastric mucosa involving the whole stomach with thickened gastric rugae and numerous polypoidal lesions. Histopathological examination showed marked hyperplasia of the foveolar glands with inflammatory cell infiltration. Endoscopic ultrasound showed a significantly hypertrophic mucosa and muscularis mucosa, while the submucosa and the muscularis propria were spared, favouring its benign nature. Colonoscopy showed multiple sessile polyps scattered at different parts of the colon. Histopathological examination revealed tubular adenomatous polyps with low-grade dysplasia. Differential diagnoses included CCS, Menterier disease (MD), other polyposis syndromes, lymphoma, amyloidosis, and gastric malignancies. The presence of alopecia, nail dystrophy, GI polyposis, markedly thickened gastric mucosa and folds, abdominal pain, weight loss, and marked foveolar gland hyperplasia; all was in favour of CCS. Lymphoma was excluded due to sparing of the muscularis propria. The presence of colonic polyps and antral and duodenal infiltration, and the absence of hypoproteinaemia decreased the possibility for MD.

conclusionThe patient was diagnosed as having CCS.

Indexed as

Case reportCronkhite-Canada syndromeGastrointestinal polyposisThickened gastric mucosa

Identifiers

PMID36303811
PMCPMC9593512

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