ReviewFrontiers in reproductive health2022
Uterine Fibroids (Leiomyomata) and Heavy Menstrual Bleeding.
Review in Frontiers in reproductive health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07390864 (Intramyometrial Ergometrine Injection Versus Intramyometrial Carbetocin Injection to Decrease Blood Loss During and After Abdominal Myomectomy), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intramyometrial Ergometrine Injection Versus Intramyometrial Carbetocin Injection to Decrease Blood Loss During and After Abdominal Myomectomy: A Randomized Clinical Trial
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Uterine fibroids in women diagnosed with acromegaly: a systematic review.Reviews in endocrine & metabolic disorders · 2024Pooled it
- The Impact of Contained Versus Uncontained Morcellation Following Laparoscopic Myomectomy on Operation Time, Pain Perception and Bleeding.The journal of obstetrics and gynaecology research · 2026Article
- Early Vascular and Morphological Response After Transvaginal Radiofrequency Ablation of Uterine Fibroids: A Doppler-Based Retrospective Study.Journal of clinical medicine · 2026Article
- Article
- Health-Related Quality of Life, Anxiety, and Stress in Women with Uterine Fibroids: A Cross-Sectional Analysis.Journal of clinical medicine · 2026Article
- Injectable Collagenase Clostridium Histolyticum as a Non-surgical Treatment for Uterine Fibroids: A Scoping Review.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Efficacy and Safety of Vilaprisan in the Treatment of Uterine Fibroids: Data from ASTEROID 5, a Phase 3 Multicenter Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Article
- Improvement in health‑related quality of life in patients with heavy menstrual bleeding after treatment and its association with hereditary bleeding disorders.BMC women's health · 2026Article
- Treatment of Uterine Fibroid-Related Heavy Menstrual Bleeding: Variations in Clinical Practice at Four Hospitals in the Netherlands.Obstetrics and gynecology international · 2026Article
- The prevalence and burden of heavy menstrual bleeding, and market access barriers of medical interventions with a focus on low- and middle-income countries: a scoping review.BMC women's health · 2025Article
- Diagnostic Value and Interobserver Reproducibility of Histopathological Features in Fumarate Hydratase-Deficient Uterine Leiomyomas.Diagnostics (Basel, Switzerland) · 2025Article
- A narrative review on the role of IL-1β, IL-8, and the endometrial matrix in heavy menstrual bleeding pathogenesis.Annals of medicine and surgery (2012) · 2025Review
- Review
- Bone mineral density with elagolix plus add-back therapy in women with heavy menstrual bleeding and uterine fibroids: open-label and post-treatment results of a 60-month phase 3 trial.AJOG global reports · 2025Article
- A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding.Communications medicine · 2025Article
- How Women Discuss Heavy Menstrual Bleeding in Online Forums ("It's Like Revenge of the Uterus"): Template Approach to Thematic Analysis.Journal of medical Internet research · 2025Article
- Biologically-Based Notions About Uterine Bleeding During Myomectomy: Reasoning on Tradition and New Concepts.Medical sciences (Basel, Switzerland) · 2025Review
- Is uterine artery embolisation a safe and effective modality to treat submucosal fibroids?CVIR endovascular · 2025Article
- Laparoscopic myomectomy without uterine manipulator for maintaining endometrial cavity integrity.Heliyon · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uterine Fibroids, or leiomyomata, affect millions of women world-wide, with a high incidence of 75% within women of reproductive age. In ~30% of patients, uterine fibroids cause menorrhagia, or heavy menstrual bleeding, and more than half of the patients experience symptoms such as heavy menstrual bleeding, pelvic pain, or infertility. Treatment is symptomatic with limited options including hysterectomy as the most radical solution. The genetic foundations of uterine fibroid growth have been traced to somatic driver mutations (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.