Evidence map›Paper›PMID 36303556›Full record

ArticleFrontiers in neurology2022

Cardiac sympathetic denervation could be associated with dysphagia in Parkinson's disease.

Jinyoung Youn, George Umemoto, Eungseok Oh, Jinse Park, Wooyoung Jang, Yoon-Sang Oh, Hee-Tae Kim, Jin Whan Cho, Shinsuke Fujioka, Yoshio Tsuboi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 2 countries.

Jinyoung YounDepartment of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea.
George UmemotoSwallowing Disorders Center, Fukuoka University Hospital, Fukuoka, Japan.
Eungseok OhDepartment of Neurology, Chungnam National University College of Medicine, Chungnam National University Hospital, Daejeon, South Korea.
Jinse ParkDepartment of Neurology, Inje University, Haeundae Paik Hospital, Busan, South Korea.
Wooyoung JangDepartment of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, South Korea.
Yoon-Sang OhDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Hee-Tae KimDepartment of Neurology, Hanyang University College of Medicine, Seoul, South Korea.
Jin Whan ChoDepartment of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea.
Shinsuke FujiokaDepartment of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Yoshio TsuboiDepartment of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Fukuoka University · JPCatholic University of Korea · KRChungnam National University Hospital · KRFukuoka University Hospital · JPGangneung Asan Hospital · KRHanyang University · KRInje University Haeundae Paik Hospital · KRSamsung Medical Center · KRSungkyunkwan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dysphagia is an important non-motor symptom that is closely associated with quality of living and mortality in Parkinson's disease (PD). However, the pathophysiology of dysphagia in PD remains inconclusive. We tried to confirm whether the occurrence of dysphagia could be related to sympathetic degeneration using cardiac Methods: We prospectively recruited 27 PD patients and classified them into two groups (PD with dysphagia vs. PD without dysphagia) by Swallowing Disturbance Questionnaire (SDQ) score and compared the clinical characteristics, videofluoroscopic swallowing study (VFSS) findings and parameters from cardiac MIBG scintigraphy. Results: The mean early and late H/M ratios were significantly lower in the PD with dysphagia group than those in the PD without dysphagia group (1.39 ± 0.21 vs. 1.86 ± 0.21, Conclusion: We confirmed that cardiac sympathetic denervation might be associated with the presence and severity of dysphagia. This finding indicates that dysphagia in PD could be associated with a nondopaminergic mechanism.

Indexed as

123I-metaiodobenzylguanidine (MIBG)dysphagianon-motor symptomsParkinson's diseaseswallowingVFSS

Identifiers

PMID36303556
PMCPMC9592804
OpenAlexW4304172431

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.