ArticleFrontiers in genetics2022
Comprehensive analysis of potential cellular communication networks in advanced osteosarcoma using single-cell RNA sequencing data.
Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Understanding and Overcoming Osteosarcoma Heterogeneity.Biomolecules · 2026Review
- Late-onset events in parosteal osteosarcoma: findings from a two-decade retrospective study.BMC cancer · 2026Article
- Integration of Circulating Immune Checkpoint Proteins and Osteopontin Refined Risk Stratification in Osteosarcoma.Cancers · 2026Article
- The ITGB2-COPS3-SOX2 Axis and SOX2 Liquid-Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-cell RNA sequencing in osteosarcoma: applications in diagnosis, prognosis, and treatment.Medical oncology (Northwood, London, England) · 2025Review
- Discovery of core genes and intercellular communication role in osteosarcoma.Journal of applied genetics · 2025Article
- Microenvironment matters: insights from the FOSTER consortium on microenvironment-driven approaches to osteosarcoma therapy.Cancer metastasis reviews · 2025Review
- Digging Through the Complexities of Immunological Approaches in Emerging Osteosarcoma Therapeutics: A Comprehensive Narrative Review with Updated Clinical Trials.Biomedicines · 2025Review
- Vascular galectins in tumor angiogenesis and cancer immunity.Seminars in immunopathology · 2024Review
- Regulation of the P53 tumor suppressor gene and the Mcl-2 oncogene expression by an active herbal component delivered through a smart thermo-pH-sensitive PLGA carrier to improve Osteosarcoma treatment.Medical oncology (Northwood, London, England) · 2024Article
- Identification of novel prognostic biomarkers for osteosarcoma: a bioinformatics analysis of differentially expressed genes in the mesenchymal stem cells from single-cell sequencing data set.Translational cancer research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteosarcoma (OS) is a common bone cancer in children and adolescents, and metastasis and recurrence are the major causes of poor treatment outcomes. A better understanding of the tumor microenvironment is required to develop an effective treatment for OS. In this paper, a single-cell RNA sequencing dataset was taken to a systematic genetic analysis, and potential signaling pathways linked with osteosarcoma development were explored. Our findings revealed 25 clusters across 11 osteosarcoma tissues, with 11 cell types including "Chondroblastic cells", "Osteoblastic cells", "Myeloid cells", "Pericytes", "Fibroblasts", "Proliferating osteoblastic cells", "Osteoclasts", "TILs", "Endothelial cells", "Mesenchymal stem cells", and "Myoblasts". The results of Cell communication analysis showed 17 potential cellular communication networks including "COLLAGEN signaling pathway network", "CD99 signaling pathway network", "PTN signaling pathway network", "MIF signaling pathway network", "SPP1 signaling pathway network", "FN1 signaling pathway network", "LAMININ signaling pathway network", "FGF signaling pathway network", "VEGF signaling pathway network", "GALECTIN signaling pathway network", "PERIOSTIN signaling pathway network", "VISFATIN signaling pathway network", "ITGB2 signaling pathway network", "NOTCH signaling pathway network", "IGF signaling pathway network", "VWF signaling pathway network", "PDGF signaling pathway network". This research may provide novel insights into the pathophysiology of OS's molecular processes.
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