Evidence map›Paper›PMID 36303431›Full record

ArticleGut microbes

The duodenal mucosa associated microbiome, visceral sensory function, immune activation and psychological comorbidities in functional gastrointestinal disorders with and without self-reported non-celiac wheat sensitivity.

Ayesha Shah, Seungha Kang, Nicholas J Talley, Anh Do, Marjorie M Walker, Erin R Shanahan, Natasha A Koloski, Michael P Jones, Simon Keely, Mark Morrison and 1 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Harnessing gut microbiome enzymes:Microbiology spectrum · 2026
    Article
  5. Article
  6. Duodenal microbiota profiling and its effects on gastrointestinal tract dysfunction.Frontiers in cellular and infection microbiology · 2026
    Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Ayesha ShahDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia.ORCID 0000-0003-0710-1691
Seungha KangFaculty of Medicine, University of Queensland, Brisbane, Australia.ORCID 0000-0003-0731-5876
Nicholas J TalleyCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, and Hunter Medical Research Institute, New Lambton Heights, Australia.ORCID 0000-0003-2537-3092
Anh DoDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia.ORCID 0000-0002-3339-4283
Marjorie M WalkerCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, and Hunter Medical Research Institute, New Lambton Heights, Australia.ORCID 0000-0002-7788-0056
Erin R ShanahanDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia.ORCID 0000-0003-4637-0851
Natasha A KoloskiDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia.ORCID 0000-0002-8647-5933
Michael P JonesCollege of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, and Hunter Medical Research Institute, New Lambton Heights, Australia.ORCID 0000-0003-0565-4938
Simon KeelySchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, and Hunter Medical Research Institute, New Lambton Heights, Australia.ORCID 0000-0002-1248-9590
Mark MorrisonDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia.ORCID 0000-0001-9257-9133
Gerald J HoltmannDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia.ORCID 0000-0002-0206-2358
Hunter Medical Research Institute · AUTranslational Research Institute · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frequently, patients with functional gastrointestinal disorders (FGIDs) report intolerance of wheat products. We compared gastrointestinal symptoms, sensory function, psychiatric comorbidities, gut-homing immune cells, and duodenal mucosa-associated microbiome (d-MAM) in FGID patients and controls with and without self-reported wheat sensitivity (SR-NCWS). We recruited 40 FGID patients and 20 controls referred by GPs for treatment. Gastrointestinal/extraintestinal symptoms, visceral sensory function, psychological comorbidities, and SR-NCWS were assessed in a standardized approach. Peripheral gut homing T-cells (CD4

Indexed as

Gastrointestinal DiseasesGastrointestinal MicrobiomeWheat HypersensitivityHumansIntestinal MucosaSelf ReportSensationDuodenumfunctional gastrointestinal disordershoming small intestinal T-cellsmucosa-associated microbiomenon-celiac wheat sensitivityself-reported wheat intolerance

Identifiers

PMID36303431
PMCPMC9621048
OpenAlexW4307452156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.