Evidence map›Paper›PMID 36303231›Full record

ArticleJournal of ovarian research2022

Insulin-like peptide 5 (INSL5) positively correlates with anti-Müllerian hormone (AMH) in women with the polycystic ovary syndrome: a case-control study.

Yijie Chen, Miao Deng, Zhaojing Chen, Shuyang Han, Jun Chen, Hongyan Zhang, Qianwen Wang, Xuejing Jin, Wenhua Liu, Zhifen Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yijie Chen *The Fourth School of Clinical Medicine, Hangzhou Women's Hospital, Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, 310008, Hangzhou, China.
Miao Deng *The Fourth School of Clinical Medicine, Hangzhou Women's Hospital, Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, 310008, Hangzhou, China.
Zhaojing ChenDepartment of Epidemiology and Health Statistics, Hangzhou Normal University School of Public Health, Hangzhou, 311121, China.
Shuyang HanDepartment of the Reproductive Endocrinology Division, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), No. 369 kunpeng Road, Shangcheng District, Hangzhou, 310008, Zhejiang, China.
Jun ChenThe Fourth School of Clinical Medicine, Hangzhou Women's Hospital, Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, 310008, Hangzhou, China.
Hongyan ZhangThe Fourth School of Clinical Medicine, Hangzhou Women's Hospital, Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, 310008, Hangzhou, China.
Qianwen WangDepartment of Obstetrics and Gynecology, Nanjing Medical University, Nanjing, 210000, China.
Xuejing JinThe Fourth School of Clinical Medicine, Hangzhou Women's Hospital, Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, 310008, Hangzhou, China.
Wenhua LiuDepartment of the Reproductive Endocrinology Division, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), No. 369 kunpeng Road, Shangcheng District, Hangzhou, 310008, Zhejiang, China.
Zhifen ZhangThe Fourth School of Clinical Medicine, Hangzhou Women's Hospital, Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, 310008, Hangzhou, China. zhangzf@zju.edu.cn.
Hangzhou Women’s Hospital · CNZhejiang Chinese Medical University · CNHangzhou Normal University · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInsulin-like peptide 5 (INSL5) is involved in both reproductive and metabolic processes in polycystic ovary syndrome (PCOS). This study aimed to evaluate the relationship between INSL5 and anti-Müllerian hormone (AMH).

methodsA retrospective case-control study was conducted in a university-based reproductive centre between December 2019 and January 2021. We included 117 women with PCOS and 100 healthy subjects from Zhejiang Province. All subjects were divided into four groups (1st-4th) based on quartiles of serum INSL5 levels. Serum INSL5 concentration was assayed using an enzyme-linked immunosorbent assay.

resultsA significant direct association was observed between serum INSL5 and AMH levels in women with PCOS. The mean AMH level in the 1st-4th INSL5 level quartiles were 4.64, 5.20, 6.46, and 9.48 ng/ml, respectively (P < 0.001). After adjusting for age, body mass index, metabolic indices, and serum levels of oestradiol and total testosterone, AMH levels remained positively and significantly associated with INSL5 levels (P for trend < 0.001). The diagnostic value of AMH was better than that of INSL5.

conclusionsINSL5 and AMH levels were significantly correlated and elevated in women with PCOS. INSL5 and AMH might be associated with increased androgen secretion and chronic anovulation in PCOS.

Indexed as

Anti-Mullerian HormonePolycystic Ovary SyndromeCase-Control StudiesFemaleHumansInsulinProteinsRetrospective StudiesAnti-Mullerian HormoneInsulinLeydig insulin-like proteinProteinsAnti-Müllerian hormoneInsulin-like peptide 5Polycystic ovary syndrome

Identifiers

PMID36303231
PMCPMC9615208
OpenAlexW4307437014

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.