Evidence map›Paper›PMID 36303197›Full record

ArticleTrials2022

Efficacy of platelet-rich plasma impregnation for unidirectional porous β-tricalcium phosphate in lateral lumbar interbody fusion: study protocol for a prospective controlled trial.

Kosuke Sato, Toru Funayama, Hiroshi Noguchi, Tomoyuki Asada, Mamoru Kono, Fumihiko Eto, Yosuke Shibao, Kosei Miura, Naoya Kikuchi, Tomokazu Yoshioka and 3 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. A Review of Synthetic Bone Grafts in Lumbar Interbody Fusion.Bioengineering (Basel, Switzerland) · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kosuke SatoDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan. junkrown@tsukuba-seikei.jp.ORCID http://orcid.org/0000-0002-5505-6496
Toru FunayamaDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan.
Hiroshi NoguchiDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan.
Tomoyuki AsadaDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan.
Mamoru KonoDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan.
Fumihiko EtoDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan.
Yosuke ShibaoDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan.
Kosei MiuraDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan.
Naoya KikuchiDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan.
Tomokazu YoshiokaDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan.
Hiroshi TakahashiDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan.
Masao KodaDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan.
Masashi YamazakiDepartment of Orthopedic Surgery, University of Tsukuba, 2-1-1 Amakubo, Tsukuba City, Ibaraki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of platelet-rich plasma has been increasing in spinal fusion surgery. However, the efficacy of platelet-rich plasma in lateral lumbar interbody fusion is unclear. In Japan, Affinos,® (Kuraray Co., Tokyo, Japan), a β-tricalcium phosphate artificial bone, has been increasingly used for spinal fusion. The purpose of this trial is to demonstrate whether Affinos® impregnated with platelet-rich plasma can achieve a higher fusion rate and better clinical outcomes than Affinos® alone.

methodsThe current study is a prospective randomized controlled trial. This trial will include consecutive patients scheduled for lateral lumbar interbody fusion. An intervertebral cage for lateral lumbar interbody fusion has two spaces for bone grafts. As a consequence, two bone grafts are inserted at each intervertebral level. In this study, an artificial bone with platelet-rich plasma will be inserted into one space, and an artificial bone without platelet-rich plasma will be inserted into the other space. We will compare the fusion rates between the bone grafts with and without platelet-rich plasma. Our primary endpoint will be the interbody fusion rate at 1 year after surgery. DISCUSSION: This trial will verify the efficacy of platelet-rich plasma with Affinos® for bony fusion in lateral lumbar interbody fusion. It will also provide substantial evidence for the effectiveness and safety of platelet-rich plasma in spinal fusion surgery.

trial registrationJapan Registry of Clinical Trials (jRCT) jRCTb032200199 . First registered on 13 November 2020. jRCT is approved as a member of the Primary Registry Network of WHO ICTRP.

Indexed as

Platelet-Rich PlasmaSpinal FusionCalcium PhosphatesHumansLumbar VertebraePorosityProspective StudiesRandomized Controlled Trials as TopicTreatment Outcomebeta-tricalcium phosphateCalcium PhosphatesFusion rateLateral lumbar interbody fusionPlatelet-rich plasmaβ-tricalcium phosphate artificial bone

Identifiers

PMID36303197
PMCPMC9615172

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.