ArticleBMC oral health2022
Effect of fixed orthodontic appliances on gingival status and oral microbiota: a pilot study.
Article in BMC oral health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07039071 (Evaluation of Clinical and Patient-Reported Outcomes of Laceback), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Clinical and Patient-Reported Outcomes of Laceback: A Split-Mouth Randomised Controlled Trial
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The influence of anorexia nervosa on oral health and related parameters potentially relevant to orthodontic treatment: a systematic review and meta-analysis.Clinical oral investigations · 2025Pooled it
- Influence of elastomeric and steel ligatures on periodontal health during fixed appliance orthodontic treatment: a systematic review and meta-analysis.Progress in orthodontics · 2024Pooled it
- Effect of fluorescein-containing toothpaste on dental plaque in patients with fixed orthodontic appliances: a randomized clinical trial.BMC oral health · 2025Trial
- Longitudinal Characterization of Gingival Microbiota Following Periodontally Accelerated Osteogenic Orthodontics Surgery in Skeletal Class III Orthognathic Patients.International dental journal · 2026Article
- Efficacy and Safety of Adding Electrolysis Device to Standard Methods of Maintaining Oral Hygiene in Patients with Fixed Orthodontic Appliance.Healthcare (Basel, Switzerland) · 2026Article
- Observational Study of the Association Between OralJournal of clinical medicine · 2026Article
- A Pilot Study on the Evaluation of Hetafu Mouthwash in Oral Biofilm of Orthodontic Patients: A Clinical Trial.Cureus · 2026Article
- Microbial and periodontal shifts induced by orthodontic appliances: a comparative clinical study.Acta odontologica Scandinavica · 2026Article
- Assessment and Evaluation of Oral Health in Orthodontic Patients: A Cross-Sectional Study.Cureus · 2025Article
- Article
- Article
- Comparison of Oral Microbial Profile Among Patients Undergoing Clear Aligner and Fixed Orthodontic Therapies for the Treatment of Malocclusions: An Updated Review.Dentistry journal · 2025Review
- Review
- Cross-omics analysis reveals microbe-metabolism interactions characteristic of gingival enlargement associated with fixed orthodontic in adolescents.Journal of oral microbiology · 2025Article
- Antibacterial Effectiveness and Periodontal Actions of Sugar-Free Chewing Gums Derived From Alcohol or Vegetables in Patients with Fixed Orthodontic Treatment: A Systematic Review.Clinical, cosmetic and investigational dentistry · 2025Review
- Comparative evaluation of antimicrobial toothpastes on periodontal bacteria in orthodontic patients: A randomized controlled study.Journal of orthodontic science · 2025Article
- Changes in subgingival microflora in patients with fixed orthodontic appliances.Dental press journal of orthodontics · 2025Article
- Dynamics of the oral microbiome during orthodontic treatment and antimicrobial advances for orthodontic appliances.iScience · 2024Review
- Knowledge, attitude, and practice toward oral health management among orthodontic patients: a cross-sectional study.BMC oral health · 2024Article
- Changes in the Oral Microbiota with the Use of Aligners vs. Braces: A Systematic Review.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis pilot study aimed to investigate how fixed orthodontic appliances simultaneously applied on the upper and lower arches affect the oral environment in the medium term.
methodsThe oral status of 30 orthodontic patients was evaluated using the number of decay-missing-filled teeth (DMFT), plaque (PI), and gingival indices (GI) before bonding of fixed orthodontic appliances (T0) and during the therapy (T1). Besides, the gingival crevicular fluid (GCF) and a dental plaque were collected. Samples were analyzed for selected Candida sp. and for 10 selected oral bacteria using mass spectroscopy and multiplex polymerase chain reaction, respectively.
resultsIn 60% of patients, deterioration of the oral status (demonstrated by the increase in PI) was recorded (p < 0.05). Moreover, the changes in PI correlated with those of GI (p < 0.001). At the T1 time point, the mean representation of Actinomyces sp. in the total prokaryotic DNA in GCF and dental plaque of individual patients increased compared to T0 (p < 0.05). The probability of finding any of the 7 selected periodontal bacteria combined with Candida sp. was 10 times higher in patients in whom PI deteriorated between T0 and T1 (p < 0.01).
conclusionsChanges in the oral microbial diversity and an increase in PI were observed in the medium term after bonding of orthodontic appliance. Our study highlights the importance of a complex approach in this type of research as the association between clinical characteristics and combined microbial parameters is higher than when evaluated separately.
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