ArticleBMC infectious diseases2022
Pyogenic spondylitis caused by Klebsiella pneumoniae: should the possibility of hypervirulent Klebsiella pneumoniae be considered?
Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Invasive pyogenic spondylitis with retropharyngeal and hepatic abscesses caused by hypermucoviscous klebsiella pneumoniae: A radiologic case report.Radiology case reports · 2025Article
- Analysis of clinical and microbiological characteristics of invasive Klebsiella pneumoniae liver abscess syndrome.BMC infectious diseases · 2025Article
- Gram-negative rods are associated with prolonged treatment in patients with thoracolumbar pyogenic spondylitis after minimally invasive posterior fixation compared with gram-positive cocci: a multicenter retrospective cohort study.BMC musculoskeletal disorders · 2025Article
- Community-Acquired Solitary Brain Abscesses Caused by HypervirulentMicroorganisms · 2024Article
- [Carbapenemase Genes, Virulence Genes, and Molecular Epidemiology of Carbapenem-ResistantSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKlebsiella pneumoniae is rare but the second most common causative agent among gram-negative bacteria that cause pyogenic spondylitis. However, there are no available studies on the serotype, virulence factors, and clinical characteristics associated with K. pneumoniae-caused pyogenic spondylitis. Accordingly, we investigated the clinical characteristics of pyogenic spondylitis, K1 and K2 serotypes, and virulence factors of K. pneumoniae.
methodsWe reviewed the microbiological reports of specimens collected between January 2014 and December 2019 as well as the medical records of patients with pyogenic spondylitis caused by K. pneumoniae. We also evaluated K1 and K2 serotypes and the virulent genes rmpA, iutA, mrkD, ybtS, entB, and kfu. Strains that possessed rmpA and iutA were defined as hypervirulent K. pneumoniae.
resultsSix patients with pyogenic spondylitis caused by K. pneumoniae were enrolled in the study. The capsular serotypes K1 and K2 were present in 66.7% (4/6) of cases, and the hypervirulent strains were present in 88.3% (5/6) of cases. All patients had community-acquired infections, and all strains isolated were susceptible to antimicrobial agents. Intravenous antibiotic treatment continued for 2-7 weeks, and no patient underwent decompressive operation or surgical debridement. There was no recurrence. One patient died from pneumonia with a septic lung.
conclusionHypervirulent K. pneumoniae is a rare but possible causative agent associated with pyogenic spondylitis.
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