ArticleNature genetics2022
Adult human kidney organoids originate from CD24
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Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
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38 citing papers in PubMed, 58 citations in OpenAlex.
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- New developments and applications of human organoids.Nature reviews. Molecular cell biology · 2026Review
- Organoids: generation strategies, applications, and future challenges.Stem cell research & therapy · 2026Review
- Modelling kidney cystogenesis using human kidney tubuloid cultures.BMC molecular and cell biology · 2026Article
- Patient-derived kidney organoids recapitulate ADPKD and facilitate the identification of Rho pathway inhibitors as candidate therapeutics.Cell reports. Medicine · 2026Article
- Monitoring biological effects of somatic cell genome editing.Nature reviews. Genetics · 2026Review
- Organoids: technology refining, current applications and future directions.Molecular biomedicine · 2026Review
- Human organoids as 3D in vitro platforms for drug discovery: opportunities and challenges.Nature reviews. Drug discovery · 2026Review
- A Human Kidney Tubuloid Model of Repeated Cisplatin-Induced Cellular Senescence and Fibrosis for Drug Screening.Advanced healthcare materials · 2026Article
- Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling.Advanced healthcare materials · 2026Article
- Technological Innovations and the Translational Path of Kidney Organoids.Biomedicines · 2026Review
- Translational Potential: Kidney Tubuloids in Precision Medicine and Regenerative Nephrology.Pharmaceutics · 2026Article
- Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects.MedComm · 2026Review
- Advances and future perspectives of kidney organoid technology in renal disease research and clinical translation.Frontiers in medicine · 2026Review
- Efficient kidney gene transfer and proximal tubule transduction using self-complementary AAV.cc47 vectors.Molecular therapy. Methods & clinical development · 2025Article
- Single-cell sequencing and organoids: applications in organ development and disease.Molecular biomedicine · 2025Review
- Organoids in Genetic Disorders: from Disease Modeling to Translational Applications.Stem cell reviews and reports · 2025Review
- CRISPR and gene editing for kidney diseases: where are we?Clinical kidney journal · 2025Review
- Complete Replication or Targeted Mimicry: Evaluating Cell Identity in Advanced In Vitro Kidney Models.Kidney360 · 2025Article
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Authors and funding
39 authors at 9 institutions in 3 countries.
Yaoxian Xu *Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Christoph Kuppe *Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0003-4597-9833
Javier Perales-PatónInstitute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0003-0780-6683
Sikander HayatInstitute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0001-5919-8371
Jennifer KranzInstitute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Ali T AbdallahInterdisciplinary Center for Clinical Research, RWTH Aachen University, Aachen, Germany.
James NagaiInstitute of Computational Genomics, RWTH Aachen University, Aachen, Germany.
Zhijian LiInstitute of Computational Genomics, RWTH Aachen University, Aachen, Germany.
Fabian PeiskerInstitute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0003-0123-8179
Turgay SaritasInstitute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0002-6691-9218
Maurice HalderInstitute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0003-2386-9684
Sylvia MenzelInstitute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Konrad HoeftInstitute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0002-0265-0061
Annegien KenterDepartment of Developmental Biology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-1040-2308
Hyojin KimInstitute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Claudia R C van RoeyenInstitute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Michael LehrkeDepartment of Cardiology, RWTH Aachen University, Aachen, Germany.
Julia MoellmannDepartment of Cardiology, RWTH Aachen University, Aachen, Germany.
Thimoteus SpeerDepartment of Nephrology, University Hospital Homburg, Homburg, Germany.ORCID http://orcid.org/0000-0002-2491-6393
Eva M BuhlInstitute of Pathology and Electron Microscopy Facility, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0003-0627-9228
Remco HoogenboezemDepartment of Hematology, Erasmus Medical Center, Rotterdam, the Netherlands.
Peter BoorDivision of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0001-9921-4284
Jitske JansenInstitute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Cordula KnoppInstitute of Human Genetics, RWTH Aachen University, Aachen, Germany.
Ingo KurthInstitute of Human Genetics, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0002-5642-8378
Bart SmeetsDepartment of Pathology, RIMLS, Radboudumc, Nijmegen, the Netherlands.
Eric BindelsDepartment of Hematology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-9502-669X
Marlies E J ReindersDepartment of Internal Medicine and Department of Nephrology and Transplantation, Erasmus Medical Center Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Carla BaanDepartment of Internal Medicine and Department of Nephrology and Transplantation, Erasmus Medical Center Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Joost GribnauDepartment of Developmental Biology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-5645-4691
Ewout J HoornDepartment of Internal Medicine and Department of Nephrology and Transplantation, Erasmus Medical Center Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Joachim SteffensDepartment of Urology, St Antonius Hospital, Eschweiler, Germany.
Tobias B HuberIII Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7175-5062
Ivan CostaInstitute of Computational Genomics, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0000-0003-2890-8697
Jürgen FloegeDivision of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Rebekka K SchneiderDepartment of Developmental Biology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-0749-1565
Julio Saez-RodriguezInstitute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Bioquant, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-8552-8976
Benjamin S FreedmanDepartment of Medicine, Division of Nephrology, Kidney Research Institute and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.
Rafael KramannInstitute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany. rkramann@gmx.net.ORCID http://orcid.org/0000-0003-4048-6351
RWTH Aachen University · DEErasmus MC · NLHeidelberg University · DERadboud University Nijmegen · NLMartin Luther University Halle-Wittenberg · DESankt-Antonius-Hospital Eschweiler · DEUniversität Hamburg · DEUniversity Hospital Magdeburg · DEUniversity of Washington · US
Funding
Tissue Chip Data to the Microphysiology Systems Database (MPS-Db) Supplement to A Microphysiological System for Kidney Disease Modeling and Drug Efficacy TestingUH3TR002158 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2019 to 2021
$4.2MA Microphysiological System for Kidney Disease Modeling and Drug Efficacy TestingUG3TR002158 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2017 to 2018
$2.9MSafety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological SystemsUH3TR003288 · NCATS · UNIVERSITY OF WASHINGTON · PI FREEDMAN, BENJAMIN SOLOMON, HIMMELFARB, JONATHAN · 2022 to 2024
$2.3MSCGE Comparative Studies SupplementU01DK127553 · NIDDK · UNIVERSITY OF WASHINGTON · PI FREEDMAN, BENJAMIN SOLOMON · 2020 to 2022
$2.2MA Human Organoid Model of Polycystic Kidney DiseaseR01DK117914 · NIDDK · UNIVERSITY OF WASHINGTON · PI FREEDMAN, BENJAMIN SOLOMON · 2018 to 2022
$1.8MSafety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological SystemsUG3TR003288 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN, KRETZLER, MATTHIAS · 2020 to 2021
$1.7MEuropean Research Council 677448NCATS NIH HHS UG3 TR002158NCATS NIH HHS UG3 TR003288NCATS NIH HHS UH3 TR002158NCATS NIH HHS UH3 TR003288NIDDK NIH HHS R01 DK117914NIDDK NIH HHS U01 DK127553
Abstract
Adult kidney organoids have been described as strictly tubular epithelia and termed tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that they originate from a distinct CD24
Indexed as
CystsPolycystic Kidney, Autosomal DominantAdultCD24 AntigenHumansKidneyOrganoidsTRPP Cation ChannelsCD24 AntigenCD24 protein, humanTRPP Cation Channels
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