Recruitment to Chromatin of (GA)n-Associated Factors GAF and Psq in the Transgenic Model System Depends on the Presence of Architectural Protein Binding Sites.

D A Chetverina, F V Gorbenko, D V Lomaev, P G Georgiev, M M Erokhin

Abstract read

In one paragraph

Article in Doklady. Biochemistry and biophysics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 51% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

D A ChetverinaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.

F V GorbenkoInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.

D V LomaevInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.

P G GeorgievInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.

M M ErokhinInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. yermaxbio@yandex.ru.

Institute of Gene Biology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycomb group (PcG) repressors and Trithorax group (TrxG) activators of transcription are essential for the proper development and maintenance of gene expression profiles in multicellular organisms. In Drosophila, PcG/TrxG proteins interact with DNA elements called PRE (Polycomb response elements). We have previously shown that the repressive activity of inactive PRE in transgenes can be induced by architectural protein-binding sites. It was shown that the induction of repression is associated with the recruitment of PcG/TrxG proteins, including the DNA-binding factors Pho and Combgap. In the present study, we tested the association of the two other PRE DNA-binding factors, GAF and Psq, with bxdPRE in the presence and absence of sites for architectural proteins. As a result, it was shown that both factors can be efficiently recruited to the bxdPRE only in the presence of adjacent binding sites for architectural proteins Su(Hw), CTCF, or Pita.

Indexed as

ChromatinDrosophila ProteinsAnimalsBinding SitesDNADNA-Binding ProteinsDrosophilaDrosophila melanogasterPolycomb-Group ProteinsPolycomb Repressive Complex 1Protein BindingChromatinDNADNA-Binding ProteinsDrosophila ProteinsPolycomb-Group ProteinsPolycomb Repressive Complex 1CTCFDrosophilaGAFPitaPolycombPREPsqrepression of transcriptionSu(Hw)

Identifiers

PMID36303054

DOI10.1134/S1607672922050039

OpenAlexW4307641917

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.