Evidence map›Paper›PMID 36303052›Full record

ArticleDoklady. Biochemistry and biophysics2022

Geldanamycin Enhances the Radioprotective Effect of Peroxyredoxin 6 in Irradiated 3T3 Fibroblasts.

E G Novoselova, O V Glushkova, M G Sharapov, M O Khrenov, S B Parfenyuk, S M Lunin, T V Novoselova, A K Mubarakshina, R G Goncharov, E E Fesenko

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Article in Doklady. Biochemistry and biophysics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

E G NovoselovaInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia. elenanov_06@mail.ru.
O V GlushkovaInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
M G SharapovInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
M O KhrenovInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
S B ParfenyukInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
S M LuninInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
T V NovoselovaInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
A K MubarakshinaInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
R G GoncharovInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
E E FesenkoInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
Institute of Cell Biophysics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to evaluate the possibility of increasing the radioprotective potential of peroxiredoxin 6 (Prdx6) and its mutant form S32A by their combined use with geldanamycin (GA) for 3T3 fibroblasts irradiated with X-rays at a dose of 6 Gy. The mutant enzyme S32A, which does not have phospholipase activity, exhibits a more pronounced radioprotective activity when combined with GA. The use of this combination of radioprotective drugs completely abolishes the peak of NF-κB activity in irradiated 3T3 cells. Another transcription factor, p53, which is an indicator of the level of cell apoptosis and increases upon irradiation, is also reduced by S32A in combination with GA. The low-molecular-weight protein p21, which is a marker of cell senescence and whose production increases upon irradiation, is also normalized when S32A is used in combination with GA. In addition, the use of this combination of radioprotective drugs significantly reduces the stress response of 3T3 cells to X-ray irradiation.

Indexed as

Radiation-Protective AgentsAnimalsBenzoquinonesFibroblastsLactams, MacrocyclicMiceBenzoquinonesgeldanamycinLactams, MacrocyclicRadiation-Protective Agents3T3 fibroblastsapoptosiscellular stresssenescence, peroxiredoxin 6, geldanamycinX-ray radiation

Identifiers

PMID36303052
OpenAlexW4307639201

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.