ArticleNature biomedical engineering2023
A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples.
Article in Nature biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Polymer-inspired mechanical metamaterials.Nature communications · 2026Article
- iEVIP: a dual-inspired intelligent platform for smart response extracellular vesicle isolation and single-vesicle profiling.Nature communications · 2026Article
- A Metamaterial Buckling-Assisted Surface-Acoustic-Wave Enabled Sensor (mBASES) for Versatile and Ultrasensitive Biomarker Detection.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- In-situ polymerization-mediated glycan density measurement on extracellular vesicle surface for acute myeloid leukemia diagnosis.Journal of nanobiotechnology · 2026Article
- Steric hindrance-mediated extracellular vesicle size fractionation for rapid prehospital diagnosis of intracerebral hemorrhage.Nature communications · 2026Article
- Smart Hydrogel Doped by Metal-Organic Frameworks for Renewable Self-Pumping Enzymatic Reactors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nanoplasmonic Sensing of Heterogeneous Extracellular Vesicles: From Bulk to Single Vesicles.Small methods · 2025Review
- Inorganic-organic hybrid metamaterials with switchable high stiffness and elasticity.Nature communications · 2025Article
- FRET imaging of glycoRNA on small extracellular vesicles enabling sensitive cancer diagnostics.Nature communications · 2025Article
- Surface-enhanced spectroscopy technology based on metamaterials.Microsystems & nanoengineering · 2025Review
- Hairpin aptamer and ROS-sensitive microcapsule-mediated glycoprotein determination for the prognosis of colorectal cancer.Mikrochimica acta · 2024Article
- Magnetic augmentation through multi-gradient coupling enables direct and programmable profiling of circulating biomarkers.Nature communications · 2024Article
- Nanoplasmonic sensors for extracellular vesicles and bacterial membrane vesicles.Nano convergence · 2024Review
- Recent advances in chemical biology tools for protein and RNA profiling of extracellular vesicles.RSC chemical biology · 2024Review
- Hydrogel-Reactive-Microenvironment Powering Reconfiguration of Polymer Architectures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Gel-Based Triboelectric Nanogenerators for Flexible Sensing: Principles, Properties, and Applications.Nano-micro letters · 2024Review
- Rapid and on-site wireless immunoassay of respiratory virus aerosols via hydrogel-modulated resonators.Nature communications · 2024Article
- Flexible sensors with zero Poisson's ratio.National science review · 2024Article
- Engineered Extracellular Vesicles Driven by Erythrocytes Ameliorate Bacterial Sepsis by Iron Recycling, Toxin Clearing and Inflammation Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Multiplexed RNA profiling by regenerative catalysis enables blood-based subtyping of brain tumors.Nature communications · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The utility of mechanical metamaterials for biomedical applications has seldom been explored. Here we show that a metamaterial that is mechanically responsive to antibody-mediated biorecognition can serve as an optical interferometric mask to molecularly profile extracellular vesicles in ascites fluid from patients with cancer. The metamaterial consists of a hydrogel responsive to temperature and redox activity functionalized with antibodies to surface biomarkers on extracellular vesicles, and is patterned into micrometric squares on a gold-coated glass substrate. Through plasmonic heating, the metamaterial is maintained in a transition state between a relaxed form and a buckled state. Binding of extracellular vesicles from the patient samples to the antibodies on the hydrogel causes it to undergo crosslinking, induced by free radicals generated via the activity of horseradish peroxidase conjugated to the antibodies. Hydrogel crosslinking causes the metamaterial to undergo fast chiral re-organization, inducing amplified changes in its mechanical deformation and diffraction patterns, which are detectable by a smartphone camera. The mechanical metamaterial may find broad utility in the sensitive optical immunodetection of biomolecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.