ArticleCommunications biology2022
Lacticaseibacillus rhamnosus Probio-M9 extends the lifespan of Caenorhabditis elegans.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 42 citations in OpenAlex.
- Strain-Dependent Fermentation Enhances the Bioactivity ofFoods (Basel, Switzerland) · 2026Article
- Lactic Acid Bacteria-Fermented Natural Products: Mechanisms and Evidence for Ageing- and Stem-Cell-Related Outcomes.Foods (Basel, Switzerland) · 2026Review
- Aging regulation by gut microbiota: molecular insights from Caenorhabditis elegans.Biogerontology · 2026Review
- Lactobacillus paragasseri ameliorates age-dependent thermotaxis decline in Caenorhabditis elegans.Scientific reports · 2026Article
- Comparative Genome Analysis and Characterization of Lacticaseibacillus Paracasei NKN344 Strain Isolated from Curd of Buffalo Milk Reared on Brackish Water Lagoons of the Eastern Indian Coast.Probiotics and antimicrobial proteins · 2026Article
- Cancer and aging: complex associations and therapeutic targets.Molecular biomedicine · 2026Review
- Lactic acid bacteria isolated from mammalian feces exhibit distinct diversity and probiotic traits.World journal of microbiology & biotechnology · 2026Article
- Non-Saccharomyces yeasts contribute to longevity, mitigated protein toxicity, and protection against abiotic stress in Caenorhabditis elegans.Archives of microbiology · 2026Article
- Gerobiotics: Exploring the Potential and Limitations of Repurposing Probiotics in Addressing Aging Hallmarks and Chronic Diseases.Probiotics and antimicrobial proteins · 2026Review
- Article
- Potential Probiotic Lacticaseibacillus rhamnosus NKU FL1-11 Prevents Aging-Related Oxidative Stress and Inflammation via mTOR and FoxO Signaling Pathways in Zebrafish.Probiotics and antimicrobial proteins · 2026Article
- Effects and mechanisms of lifespan extension and healthspan promotion induced byFrontiers in nutrition · 2026Article
- Exploring the intricate link between gut microbiota dysbiosis and the aging process: implications for age-related diseases.Gut pathogens · 2025Review
- Microbial metabolites as engines of behavioral variation across animals.Gut microbes · 2025Review
- Enhancing the Anti-Aging Potential of Green Tea Extracts Through Liquid-State Fermentation withFoods (Basel, Switzerland) · 2025Article
- Article
- Structure-activity relationship of ginsenoside derivatives with different glycosides and double bond position on anti-aging bioactivities.Journal of ginseng research · 2025Article
- Enterococcus faecalis SI-FC-01 enhances the stress resistance and healthspan of C. elegans via AKT signaling pathway.Scientific reports · 2025Article
- Article
- The protective effects and mechanisms of rosmarinic acid againstFrontiers in pharmacology · 2025Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Probiotics have been characterized as useful for maintaining the balance of host gut flora and conferring health effects, but few studies have focused on their potential for delaying aging in the host. Here we show that Lacticaseibacillus rhamnosus Probio-M9 (Probio-M9), a healthy breast milk probiotic, enhances the locomotor ability and slows the decline in muscle function of the model organism Caenorhabditis elegans. Live Probio-M9 significantly extends the lifespan of C. elegans in a dietary restriction-independent manner. By screening various aging-related mutants of C. elegans, we find that Probio-M9 extends lifespan via p38 cascade and daf-2 signaling pathways, independent on daf-16 but dependent on skn-1. Probio-M9 protects and repairs damaged mitochondria by activating mitochondrial unfolded protein response. The significant increase of amino acids, sphingolipid, galactose and fatty acids in bacterial metabolites might be involved in extending the lifespan of C. elegans. We reveal that Probio-M9 as a dietary supplementation had the potential to delay aging in C. elegans and also provide new methods and insights for further analyzing probiotics in improving host health and delaying the occurrence of age-related chronic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.