ArticleNature communications2022
Aversive memory formation in humans involves an amygdala-hippocampus phase code.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Salient experiences enhance mundane memories through graded prioritization.Science advances · 2025Pooled it
- Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.iScience · 2026Review
- Behavioural separation of face memory and face perception.Nature communications · 2026Article
- Downregulation of UQCRC1 Expression Leads to Cognitive Decline by Disrupting the Cilia in the Dentate Gyrus.Neuroscience bulletin · 2026Article
- Novelty, Ecological Relevance, and Sexual Receptivity Modulate Neuronal Interactions between the Amygdala and Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Emotional arousal enhances narrative memories through functional integration of large-scale brain networks.Nature human behaviour · 2026Article
- Dual targeting of iNOS and Src tyrosine kinase as a superior therapeutic strategy against soman-induced long-term neurotoxicity: multimodal biomarker, imaging, and neurobehavioral outcome analyses.Acta neuropathologica communications · 2026Article
- Reactive Microglia-Mediated Synaptic Engulfment in the Basolateral Amygdala may Contribute to Preoperative Anxiety-Induced Postoperative Hyperalgesia.Neurochemical research · 2026Article
- Representational dynamics during extinction of fear memories in the human brain.Nature human behaviour · 2026Article
- Beta bursts mediate amygdala gating of hippocampal emotional encoding.bioRxiv : the preprint server for biology · 2025Article
- Can Theta Burst Electromagnetic Fields Disrupt Learning in Planaria? Evidence of Impaired Fear-Conditioned Responses.Bioelectromagnetics · 2025Article
- Neurophysiological evidence of human hippocampal longitudinal differentiation in associative memory.Nature communications · 2025Article
- Human hippocampal reactivation of amygdala encoding-related gamma patterns during aversive memory retrieval.Nature communications · 2025Article
- Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans.bioRxiv : the preprint server for biology · 2025Article
- Models of human hippocampal specialization: a look at the electrophysiological evidence.Trends in cognitive sciences · 2025Review
- Effects of Sildenafil on Cognitive Function Recovery and Neuronal Cell Death Protection after Transient Global Cerebral Ischemia in Gerbils.Biomedicines · 2024Article
- Distributed and dynamical communication: a mechanism for flexible cortico-cortical interactions and its functional roles in visual attention.Communications biology · 2024Article
- Neuronal population representation of human emotional memory.Cell reports · 2024Article
- Overnight neuronal plasticity and adaptation to emotional distress.Nature reviews. Neuroscience · 2024Review
- The central renin-angiotensin system: A genetic pathway, functional decoding, and selective target engagement characterization in humans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
13 authors at 10 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory for aversive events is central to survival but can become maladaptive in psychiatric disorders. Memory enhancement for emotional events is thought to depend on amygdala modulation of hippocampal activity. However, the neural dynamics of amygdala-hippocampal communication during emotional memory encoding remain unknown. Using simultaneous intracranial recordings from both structures in human patients, here we show that successful emotional memory encoding depends on the amygdala theta phase to which hippocampal gamma activity and neuronal firing couple. The phase difference between subsequently remembered vs. not-remembered emotional stimuli translates to a time period that enables lagged coherence between amygdala and downstream hippocampal gamma. These results reveal a mechanism whereby amygdala theta phase coordinates transient amygdala -hippocampal gamma coherence to facilitate aversive memory encoding. Pacing of lagged gamma coherence via amygdala theta phase may represent a general mechanism through which the amygdala relays emotional content to distant brain regions to modulate other aspects of cognition, such as attention and decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.