Evidence map›Paper›PMID 36302634›Full record

ArticleBiological chemistry2022

Heme delivery to heme oxygenase-2 involves glyceraldehyde-3-phosphate dehydrogenase.

Yue Dai, Angela S Fleischhacker, Liu Liu, Sara Fayad, Amanda L Gunawan, Dennis J Stuehr, Stephen W Ragsdale

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Key roles of GAPDH, Hsp90, and NO in heme trafficking.Journal of inorganic biochemistry · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Moonlighting enzymes: when cellular context defines specificity.Cellular and molecular life sciences : CMLS · 2023
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yue DaiDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, NC-22, 9500 Euclid Avenue, Cleveland, OH 44195, USA.ORCID 0000-0001-9368-7769
Angela S FleischhackerDepartment of Biological Chemistry, University of Michigan, 1150 W. Medical Center Dr., 5301 MSRB III, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0818-3203
Liu LiuDepartment of Biological Chemistry, University of Michigan, 1150 W. Medical Center Dr., 5301 MSRB III, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6737-5999
Sara FayadDepartment of Biological Chemistry, University of Michigan, 1150 W. Medical Center Dr., 5301 MSRB III, Ann Arbor, MI 48109, USA.
Amanda L GunawanDepartment of Biological Chemistry, University of Michigan, 1150 W. Medical Center Dr., 5301 MSRB III, Ann Arbor, MI 48109, USA.ORCID 0000-0003-2133-8185
Dennis J StuehrDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, NC-22, 9500 Euclid Avenue, Cleveland, OH 44195, USA.ORCID 0000-0002-0960-6848
Stephen W RagsdaleDepartment of Biological Chemistry, University of Michigan, 1150 W. Medical Center Dr., 5301 MSRB III, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3938-8906
University of Michigan · USCleveland Clinic Lerner College of Medicine · US

Funding

Metalloprotein Mechanisms of Redox Regulation and CatalysisR35GM141758 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAGSDALE, STEPHEN WILEY · 2021 to 2025
$3.0M
Heme-, Redox-, and CO-dependent Regulation of Heme HomeostasisR01HL163530 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Stephen Wiley Ragsdale · 2023 to 2026
$2.5M
Coordinate control of hemeprotein maturation and function by cell chaperones, heme, and nitric oxideR01GM130624 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI STUEHR, DENNIS J · 2019 to 2022
$1.9M
Redox Regulation of Heme Oxygenase-2 and the Nuclear Receptor Rev-Erb-beta by their Heme Responsive MotifsR01GM123513 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAGSDALE, STEPHEN WILEY · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL163530NIGMS NIH HHS R01 GM123513NIGMS NIH HHS R01 GM130624NIGMS NIH HHS R35 GM141758
6 · The paper itself

Abstract

Heme regulatory motifs (HRMs) are found in a variety of proteins with diverse biological functions. In heme oxygenase-2 (HO2), heme binds to the HRMs and is readily transferred to the catalytic site in the core of the protein. To further define this heme transfer mechanism, we evaluated the ability of GAPDH, a known heme chaperone, to transfer heme to the HRMs and/or the catalytic core of HO2. Our results indicate GAPDH and HO2 form a complex

Indexed as

HemeHeme Oxygenase (Decyclizing)Glyceraldehyde-3-Phosphate DehydrogenasesHEK293 CellsHumansGlyceraldehyde-3-Phosphate DehydrogenasesHemeheme oxygenase-2Heme Oxygenase (Decyclizing)chaperoneGAPDHglyceraldehyde-3-phosphate dehydrogenaseheme oxygenase-2heme regulatory motifsheme trafficking

Identifiers

PMID36302634
PMCPMC9661526
OpenAlexW4307434342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.