ArticleEuropean heart journal2022
Physical activity volume, intensity, and incident cardiovascular disease.
Article in European heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
95 citing papers in PubMed, 3 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- A systematic review of physical activity guidelines for adults with cardio-respiratory diseases: Stepping towards evidence-based recommendations.Clinical rehabilitation · 2026Pooled it
- Heart Rate Monitors for the Estimation of Physical Activity in Patients With Cardiovascular Disease: Systematic Review.JMIR mHealth and uHealth · 2026Pooled it
- Sex Differences in the Incidence of Sudden Cardiac Arrest/Death in Competitive Athletes: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Effect of a behavioral counseling for adoption and maintenance of a physically active lifestyle on long-term mortality in people with type 2 diabetes: post hoc analysis of the Italian Diabetes and Exercise Study_2.Nature communications · 2026Trial
- Hepatic metabolic adaptation to endurance exercise: temporal and sex differences by multiomics integration and validation.Cell communication and signaling : CCS · 2026Article
- Association of wearableZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Affective memories of school physical education, life-phase timing of formative experiences, and adult sport and exercise participation: a quota-representative study in Germany.BMC public health · 2026Article
- Accelerometer-measured physical activity fragmentation and incident cardiovascular diseases: a prospective cohort study.Nutrition journal · 2026Article
- Comparative Predictive Value of Three Visceral Adiposity Indices for Cardiovascular Disease: A 17.5-Year Korean Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Contemporary concepts in 'exercise as medicine' and related fields.Experimental physiology · 2026Article
- Multi-organ imaging and genetics show the impact of sleep patterns on the human brain and body.Communications medicine · 2026Article
- Physical activity moderates the relationship between hot flashes and arterial wave reflection in perimenopausal females.Physiological reports · 2026Article
- Physical Exercise After Fragility Fractures: A Systematic Review and Meta-Analysis of Function and Morbidity.Journal of clinical medicine · 2026Review
- Association of Physical Activity With Aortic Stiffness in the Jackson Heart Study.American journal of hypertension · 2026Article
- Differential Associations of Lipid Profiles with Dementia and Cardiovascular Disease: Findings from the UK Biobank Cohort.Yonsei medical journal · 2026Article
- Effects of healthy lifestyles on the association between food security and all-cause mortality risk.The international journal of behavioral nutrition and physical activity · 2026Article
- Metabolic syndromes mediate the association between depression and cardiovascular diseases in the UK Biobank Population Study.Comprehensive psychoneuroendocrinology · 2026Article
- Physical activity, sedentary behaviour, and exocrine and endocrine pancreatic diseases: results from a prospective cohort study and Mendelian randomization.Gastroenterology report · 2026Article
- Metabolomic signatures connect and mediate sedentary time-driven mortality risk in patients with cardiovascular disease.Frontiers in sports and active living · 2026Article
- Expert perspectives on exposure-response functions for urban health policy: Lessons from a UBDPolicy workshop.Environmental research · 2026Review
35 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
aimsThe interplay between physical activity (PA) volume and intensity is poorly understood in relation to cardiovascular disease (CVD) risk. This study aimed to investigate the role of PA intensity, over and above volume, in relation to incident CVD. METHODS AND
resultsData were from 88 412 UK Biobank middle-aged adults (58% women) without prevalent CVD who wore accelerometers on their dominant wrist for 7 days, from which we estimated total PA energy expenditure (PAEE) using population-specific validation. Cox proportional hazards regressions modelled associations between PAEE (kJ/kg/day) and PA intensity (%MVPA; the fraction of PAEE accumulated from moderate-to-vigorous-intensity PA) with incident CVD (ischaemic heart disease or cerebrovascular disease), adjusted for potential confounders. There were 4068 CVD events during 584 568 person-years of follow-up (median 6.8 years). Higher PAEE and higher %MVPA (adjusted for PAEE) were associated with lower rates of incident CVD. In interaction analyses, CVD rates were 14% (95% confidence interval: 5-23%) lower when MVPA accounted for 20% rather than 10% of 15 kJ/kg/d PAEE; equivalent to converting a 14 min stroll into a brisk 7 min walk. CVD rates did not differ significantly between values of PAEE when the %MVPA was fixed at 10%. However, the lowest CVD rates were observed for combinations of both higher PAEE and %MVPA.
conclusionReductions in CVD risk may be achievable through higher PA volume and intensity, with the role of moderately intense PA appearing particularly important. This supports multiple approaches or strategies to PA participation, some of which may be more practical or appealing to different individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.