ArticleScience (New York, N.Y.)2022
Stereochemical editing logic powered by the epimerization of unactivated tertiary stereocenters.
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Diastereomer Resolution and Structural-Property Relationship of Phosphorus-Chirogenic Luminescent α-Aminophosphaphenanthrenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- 1,2-Migration of oxamoyl-protected alcohols via reversible C-H sampling.National science review · 2026Article
- Data-Driven Approach to Understanding Tetrabutylammonium Decatungstate-Catalyzed C(spAngewandte Chemie (International ed. in English) · 2026Article
- Article
- Synergistic decatungstate and Brønsted acid catalysis enables direct C-H indolation of alkanes and aldehydes.Chemical science · 2026Article
- Distance-Dependent, Rate-Accelerating and Diastereoselective Directing Effects in Decatungstate-Mediated Stereoediting Reactions.Journal of the American Chemical Society · 2026Article
- Selective epimerization of GlcNAc to GalNAc through steady-state tuning under kinetic network control.Nature chemistry · 2026Article
- Overriding Stereochemical Outcomes in Cyclase Phase Total Synthesis: Enantioselective Synthesis of Habiterpenol and Dasyscyphin A.Journal of the American Chemical Society · 2026Article
- Photocatalytic Stereoselective Editing of Alkynes to 3D Molecules via Hydrogen Atom Transfer-Mediated Dynamic Epimerization.Nature communications · 2026Article
- Harnessing Photochemistry in Natural Product Synthesis: From Strategy to Applications.Journal of natural products · 2025Review
- Evaluations of Quinone/Hydroquinone Couples Acting as Two Hydrogen Atoms Antioxidants, Radical Quenchers, and Hydrogen Atom Abstractors.Biomolecules · 2025Article
- Migrating Group Strategy for Remote Functionalization of Seven-Membered Rings.Journal of the American Chemical Society · 2025Article
- Kinetics, Thermodynamics, and Emergence in Stereoediting Reactions.Accounts of chemical research · 2025Article
- Dynamic Kinetic Asymmetric Hydroacylation: Racemization by Soft Enolization.Journal of the American Chemical Society · 2025Article
- Mild Hydroalkylation of Terminal Olefins Via Decatungstate/Thiol Cooperative Photocatalysis.Organic letters · 2025Article
- Article
- Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding.ACS chemical biology · 2025Article
- Photocatalyzed Epimerization of Quaternary Stereocenters.Journal of the American Chemical Society · 2025Article
- Photoenolization ofJournal of the American Chemical Society · 2025Article
- Interrogation of Enantioselectivity in the Photomediated Ring Contractions of Saturated Heterocycles.Journal of the American Chemical Society · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The stereoselective synthesis of complex targets requires the precise orchestration of chemical transformations that simultaneously establish the connectivity and spatial orientation of desired bonds. In this work, we describe a complementary paradigm for the synthesis of chiral molecules and their isomers, which tunes the three-dimensional structure of a molecule at a late stage. Key to the success of this strategy is the development of a mild and highly general photocatalytic method composed of decatungstate polyanion and disulfide cocatalysts, which enable the interconversion of unactivated tertiary stereogenic centers that were previously configurationally fixed. We showcase the versatility of this method-and the implementation of stereoediting logic-by the rapid construction of chiral scaffolds that would be challenging to access using existing tools and by the late-stage stereoediting of complex targets.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.