ArticleScience (New York, N.Y.)2022
Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice.
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Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.
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136citing papers in PubMed
14.8field-weighted citation impact, top 1% of its field
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Who cites it
136 citing papers in PubMed, 184 citations in OpenAlex.
- Mitochondrial transfer-driven immune evasion in the tumor microenvironment.International immunology · 2026Review
- SAT1-Induced Spermidine Depletion Potentiates Food Allergy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spermidine attenuates monocrotaline-induced pulmonary arterial hypertension with HADHA-associated improvements in fatty acid oxidation and mitochondrial redox homeostasis.Redox biology · 2026Article
- Matrix polyamines regulate bidirectional calcium flux through MCU.Structure (London, England : 1993) · 2026Article
- T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy.Signal transduction and targeted therapy · 2026Review
- Oral nano-delivery of a gut microbial metabolite enhances T cell stemness for cancer immunotherapy.Nature nanotechnology · 2026Article
- Pentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia-reperfusion injury in the heart.Nature metabolism · 2026Article
- Spermidine in Colorectal cancer: friend or foe?Amino acids · 2026Review
- Comprehensive transcriptomic profiling reveals impaired polyamine metabolism as a contributor to age-related muscle decline.iScience · 2026Article
- Natural Bioactive Compounds Targeting Key Hallmarks of Aging: Functional Food Potential of Spermidine, Fisetin, Berberine, and Urolithin A.Nutrients · 2026Review
- Implications of Rho GTPase signaling in cancer immunotherapy.Biochemical Society transactions · 2026Review
- Metabolomics in breast cancer: insights into treatment responses, disease progression, and prognostic assessment.Metabolomics : Official journal of the Metabolomic Society · 2026Review
- HKDC1-mediated polyamine rewiring drives lenvatinib resistance and immune escape in hepatocellular carcinoma.Clinical and molecular hepatology · 2026Article
- Decoding the role of polyamine metabolism in lung adenocarcinoma prognosis: A triangulated approach combining transcriptome, single-cell and Mendelian randomization analyses.Oncology letters · 2026Article
- Adaptive resistance in cancer immunotherapy.Cellular & molecular immunology · 2026Review
- Skeletal muscle-specific myostatin overexpression promotes muscle oxidative capacity and fatigue resistance in transgenic mice.Experimental physiology · 2026Article
- The competition of amino acid among tumors, tumor-associated macrophages and T cells based on metabolic reprogramming.iScience · 2026Review
- Intermediate accumulated upon interruption of fatty acid oxidation flux promotes tumoral ferroptosis and improves immunotherapy.Nature communications · 2026Article
- Metabolites as signalling molecules in the tumour immune microenvironment.Nature reviews. Immunology · 2026Review
- Polyamine sequestration of 2'3'-cGAMP constrains intercellular transmission and STING engagement to subvert antitumor immunity.The Journal of clinical investigation · 2026Article
76 more citing papers are in PubMed but not listed here.
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Authors and funding
22 authors at 5 institutions in 4 countries.
Muna Al-Habsi *Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-2860-256X
Kenji Chamoto *Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0001-8625-3612
Ken Matsumoto *Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan.ORCID 0000-0002-3899-3672
Norimichi Nomura *Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-6330-2239
Baihao ZhangLaboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.ORCID 0000-0002-3456-2509
Yuki SugiuraDepartment of Biochemistry, Keio University, Tokyo, Japan.ORCID 0000-0002-6983-8958
Kazuhiro SonomuraCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Aprilia MaharaniDivision of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-2223-3222
Yuka NakajimaDivision of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-7357-2910
Yibo WuYCI Laboratory for Next-Generation Proteomics, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.ORCID 0000-0002-8256-3901
Yayoi NomuraDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Rosemary MenziesDivision of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-1894-5657
Masaki TajimaDivision of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0003-3407-0229
Koji KitaokaDivision of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0003-1249-6384
Yasuharu HakuDivision of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-5708-9275
Sara DelghandiDivision of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-8838-0145
Keiko YurimotoDivision of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-5854-8533
Fumihiko MatsudaCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0003-4557-4553
So IwataDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0003-1735-2937
Toshihiko OguraDepartment of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan.ORCID 0000-0002-3001-1443
Sidonia FagarasanDivision of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0003-2086-6402
Tasuku HonjoDivision of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0003-2300-3928
Kyoto University · JPInstitute of Aging · CAKeio University · JPRIKEN Center for Integrative Medical Sciences · JPUniversity of Geneva · CH
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spermidine (SPD) delays age-related pathologies in various organisms. SPD supplementation overcame the impaired immunotherapy against tumors in aged mice by increasing mitochondrial function and activating CD8
Indexed as
CD8-Positive T-LymphocytesMitochondriaMitochondrial Trifunctional Protein, alpha SubunitMitochondrial Trifunctional Protein, beta SubunitNeoplasmsSpermidineAnimalsLymphocyte ActivationMiceMitochondrial Trifunctional Protein, alpha SubunitMitochondrial Trifunctional Protein, beta SubunitSpermidine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.