ArticlePloS one2022
Asymmetrical lineage introgression and recombination in populations of Aspergillus flavus: Implications for biological control.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Current status of aflatoxin contamination and mitigation efforts in mozambique: a systematic review.Mycotoxin research · 2026Pooled it
- Genetic diversity and reproductive modes of aflatoxin-producing Aspergillus flavus isolated from cashew nuts in coastal Kenya.World journal of microbiology & biotechnology · 2025Article
- Article
- Article
- Structure of Aspergillus flavus populations associated with maize in Greece, Spain, and Serbia: Implications for aflatoxin biocontrol on a regional scale.Environmental microbiology reports · 2024Article
- Mitigation of aflatoxin contamination of maize, groundnut, and sorghum by commercial biocontrol products in farmers' fields across Burkina Faso, Mali, Niger, and Togo.CABI agriculture and bioscience · 2024Article
- Keeping toxigenicFrontiers in microbiology · 2024Article
- Genetic Diversity ofFoods (Basel, Switzerland) · 2023Article
- Soil and Phytomicrobiome for Plant Disease Suppression and Management under Climate Change: A Review.Plants (Basel, Switzerland) · 2023Review
- Article
- Recombination-aware phylogeographic inference using the structured coalescent with ancestral recombination.PLoS computational biology · 2022Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus flavus is an agriculturally important fungus that causes ear rot of maize and produces aflatoxins, of which B1 is the most carcinogenic naturally-produced compound. In the US, the management of aflatoxins includes the deployment of biological control agents that comprise two nonaflatoxigenic A. flavus strains, either Afla-Guard (member of lineage IB) or AF36 (lineage IC). We used genotyping-by-sequencing to examine the influence of both biocontrol agents on native populations of A. flavus in cornfields in Texas, North Carolina, Arkansas, and Indiana. This study examined up to 27,529 single-nucleotide polymorphisms (SNPs) in a total of 815 A. flavus isolates, and 353 genome-wide haplotypes sampled before biocontrol application, three months after biocontrol application, and up to three years after initial application. Here, we report that the two distinct A. flavus evolutionary lineages IB and IC differ significantly in their frequency distributions across states. We provide evidence of increased unidirectional gene flow from lineage IB into IC, inferred to be due to the applied Afla-Guard biocontrol strain. Genetic exchange and recombination of biocontrol strains with native strains was detected in as little as three months after biocontrol application and up to one and three years later. There was limited inter-lineage migration in the untreated fields. These findings suggest that biocontrol products that include strains from lineage IB offer the greatest potential for sustained reductions in aflatoxin levels over several years. This knowledge has important implications for developing new biocontrol strategies.
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