Evidence map›Paper›PMID 36301712›Full record

ArticleJournal of the American Chemical Society2022

Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge.

Siwen Wang, Zhonghan Li, Desiree Aispuro, Nathan Guevara, Juno Van Valkenburgh, Boxi Chen, Xiaoyun Zhou, Matthew N McCarroll, Fei Ji, Xu Cong and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Enteral Route Nanomedicine for Cancer Therapy.International journal of nanomedicine · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Siwen WangDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Zhonghan LiDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Desiree AispuroDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Nathan GuevaraDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Juno Van ValkenburghDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States.
Boxi ChenDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Xiaoyun ZhouDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States.
Matthew N McCarrollDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States.
Fei JiDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Xu CongDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Priyanka SarkarDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Rohit ChaudhuriDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Zhili GuoDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Nicole P PerkinsDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Shiqun ShaoDepartment of Chemistry, University of California, Riverside, California 92521, United States.ORCID 0000-0001-7029-3791
Jason K SelloDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States.
Kai ChenDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States.ORCID 0000-0002-8647-1182
Min XueDepartment of Chemistry, University of California, Riverside, California 92521, United States.ORCID 0000-0002-8136-6551
University of California, Riverside · USUniversity of Southern California · USUniversity of California, San Francisco · US

Funding

Research Training in Environmental ToxicologyT32ES018827 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2010 to 2026
$5.3M
Interrogation and interpretation of protein kinase signaling dynamics at single-cell resolutionR35GM138214 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Min Xue · 2020 to 2026
$2.2M
Multiplex single-cell analysis of intracellular protein signaling dynamicsR21EB025393 · NIBIB · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI XUE, MIN · 2019 to 2021
$618k
NIBIB NIH HHS R21 EB025393NIEHS NIH HHS T32 ES018827NIGMS NIH HHS R35 GM138214
6 · The paper itself

Abstract

Delivering cargo molecules across the plasma membrane is critical for biomedical research, and the need to develop molecularly well-defined tags that enable cargo transportation is ever-increasing. We report here a hydrophilic endocytosis-promoting peptide (EPP6) rich in hydroxyl groups with no positive charge. EPP6 can transport a wide array of small-molecule cargos into a diverse panel of animal cells. Mechanistic studies revealed that it entered the cells through a caveolin- and dynamin-dependent endocytosis pathway, mediated by the surface receptor fibrinogen C domain-containing protein 1. After endocytosis, EPP6 trafficked through early and late endosomes within 30 min. Over time, EPP6 partitioned among cytosol, lysosomes, and some long-lived compartments. It also demonstrated prominent transcytosis abilities in both

Indexed as

Cell-Penetrating PeptidesEndocytosisAnimalsEndosomesHydrophobic and Hydrophilic InteractionsLysosomesCell-Penetrating Peptides

Identifiers

PMID36301712
PMCPMC9650711
OpenAlexW4307407413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.