SynthesisJournal of medical Internet research2022
Effectiveness of Computerized Cognitive Training in Delaying Cognitive Function Decline in People With Mild Cognitive Impairment: Systematic Review and Meta-analysis.
Synthesis in Journal of medical Internet research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06598163 (Efficacy of a Digital Health App Five Lives MED to Improve Cognitive Function in Patients With Mild Cognitive Impairment), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of a Digital Health App Five Lives MED to Improve Cognitive Function in Patients With Mild Cognitive Impairment: a Randomised Controlled Trial
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Bayesian network meta-analysis of the effects of different cognitive interventions on cognitive function in older adults with cognitive impairment.Frontiers in public health · 2026Pooled it
- The influence of eight cognitive training regimes upon cognitive screening tool performance in post-stroke survivors: a network meta-analysis.Frontiers in aging neuroscience · 2024Pooled it
- Topical Cellular/Tissue and Molecular Aspects Regarding Nonpharmacological Interventions in Alzheimer's Disease-A Systematic Review.International journal of molecular sciences · 2023Pooled it
- A study on the effects of CCRT on cognitive function and blood biomarkers in community-dwelling older adults with MCI.BMC geriatrics · 2026Trial
- The effects of cognitive training on driving performance.Cognitive processing · 2025Trial
- Efficacy of a Mobile-Based Multidomain Intervention to Improve Cognitive Function and Health-Related Outcomes Among Older Korean Adults with Subjective Cognitive Decline.Journal of Alzheimer's disease : JAD · 2023Trial
- AI-driven telerehabilitation for older adults with mild cognitive impairment: a randomized controlled trial.Frontiers in neurologyTrial
- Symptomatic treatment for Alzheimer disease: current evidence and future directions.Nature reviews. Neurology · 2026Review
- Enhancing Cognitive Functions of Older Adults With Software Robot: Longitudinal Exploratory Field Study.JMIR mHealth and uHealth · 2026Article
- Efficacy of sequential aerobic exercise and cognitive training in older adults with amnestic mild cognitive impairment.Aging and health research · 2026Article
- Usability and feasibility of INFORMA platform for computerized cognitive stimulation in mild cognitive impairment and early dementia: an 8-week multicenter study.Aging clinical and experimental research · 2026Article
- Differential Transfer Effects Across Tasks in Younger and Older Adults Following Executive Function Training.Journal of cognitive enhancement : towards the integration of theory and practice · 2026Article
- A novel virtual reality-integrated multi-modal intervention for community-dwelling older adults with mild cognitive impairment: protocol for a randomized controlled trial.Frontiers in aging neuroscience · 2026Article
- Impact of a virtual reality program on the cognitive and psycho-emotional state of seniors with mild cognitive impairment.Frontiers in medicine · 2026Article
- Cognitive training effects in mild cognitive impairment with and without amyloid pathology.Dementia & neuropsychologia · 2026Article
- The Effects of Computerized Cognitive Training via Tablet and Computer Platforms on Cognitive Function in Patients with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2025Review
- Changes in Housework Frequency and Subsequent Cognitive Function and Rate of Decline Among Adults Aged ≥ 65 in the United States, 2008-2018.The Permanente journal · 2025Article
- A Generative AI Framework for Cognitive Intervention in Older Adults: An Integrated Engineering Design and Clinical Protocol.Healthcare (Basel, Switzerland) · 2025Article
- Domain-Specific Evaluation of Exergame Metrics Among Older Adults With Mild Neurocognitive Disorder: Secondary Analysis of 2 Randomized Controlled Trials.JMIR serious games · 2025Article
- Exploring the Discontinuous Usage Behavior of Digital Cognitive Training Among Older Adults With Mild Cognitive Impairment and Their Family Members: Qualitative Study Using the Extended Model of IT Continuance.Journal of medical Internet research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith no current cure for mild cognitive impairment (MCI), delaying its progression could significantly reduce the disease burden and improve the quality of life for patients with MCI. Computerized cognitive training (CCT) has recently become a potential instrument for improvement of cognition. However, the evidence for its effectiveness remains limited.
objectiveThis systematic review aims to (1) analyze the efficacy of CCT on cognitive impairment or cognitive decline in patients with MCI and (2) analyze the relationship between the characteristics of CCT interventions and cognition-related health outcomes.
methodsA systematic search was performed using MEDLINE, Cochrane, Embase, Web of Science, and Google Scholar. Full texts of randomized controlled trials of CCT interventions in adults with MCI and published in English language journals between 2010 and 2021 were included. Overall global cognitive function and domain-specific cognition were pooled using a random-effects model. Sensitivity analyses were performed to determine the reasons for heterogeneity and to test the robustness of the results. Subgroup analyses were performed to identify the relationship between the characteristics of CCT interventions and cognition-related effectiveness.
resultsA total of 18 studies with 1059 participants were included in this review. According to the meta-analysis, CCT intervention provided a significant but small increase in global cognitive function compared to that in the global cognitive function of the control groups (standardized mean difference=0.54, 95% CI 0.35-0.73; I
conclusionsThis systematic review suggests that CCT interventions could improve global cognitive function in patients with MCI. Considering the relatively small sample size and the short treatment duration in all the included studies, more comprehensive trials are needed to quantify both the impact of CCT on cognitive decline, especially in the longer term, and to establish whether CCT should be recommended for use in clinical practice.
trial registrationPROSPERO International Prospective Register of Systematic Reviews CRD42021278884; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=278884.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.