ReviewCannabis and cannabinoid research2023
Cannabis in Adolescence: Lasting Cognitive Alterations and Underlying Mechanisms.
Review in Cannabis and cannabinoid research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents.Molecular psychiatry · 2025Pooled it
- Long-term effects of adolescent THC exposure on anxiety-like behavior and cognitive function in male rats.Psychopharmacology · 2026Article
- Age-Related Effects of Cannabis and Cannabinoids on Brain and Behavior.Cannabis and cannabinoid research · 2026Review
- Trends in hospitalizations for cannabinoid hyperemesis syndrome in Canada, 2016-17 to 2024-25.Frontiers in public health · 2026Article
- Sex differences in factors associated with cannabis use among emerging adults.Frontiers in psychology · 2026Article
- Cannabis use frequency may differentially impact cognitive performance in young adults with and without HIV.Frontiers in adolescent medicine · 2026Article
- No Evidence That Preoperative Marijuana Use Influences the Success of Hip Arthroscopy for Femoracetabular Impingement in Adolescents and Young Adults.Orthopaedic journal of sports medicine · 2025Article
- The role of bias-based bullying in regular cannabis use among adolescents.Addictive behaviors · 2025Article
- Regular cannabis use and promotive attitudes among diverse adolescents in the United States: The role of age and intersecting social positions.Drug and alcohol dependence · 2025Article
- New Insights Into the Neural Consequences of Synthetic Cannabinoids During Adolescence: The Critical Role of Reelin at Prefrontal Synapses.Biological psychiatry global open science · 2025Article
- Reelin Deficiency and Synaptic Impairment in the Adolescent Prefrontal Cortex Following Initial Synthetic Cannabinoid Exposure.Biological psychiatry global open science · 2025Article
- Young Age and Concomitant Cannabis (THC) and Ethanol (EtOH) Exposure Enhances Rat Brain Damage Through Decreased Cerebral Mitochondrial Respiration.Molecules (Basel, Switzerland) · 2025Article
- Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats.Psychopharmacology · 2025Article
- Age-specific effects of synthetic cannabinoids on cognitive function and hippocampal gene expression in mice: insights from behavioral and molecular correlates.Frontiers in pharmacology · 2025Article
- Young Adult Cannabis Use and Circulating Endocannabinoid Concentrations on Cognitive Performance.Frontiers in adolescent medicine · 2025Article
- Correlates of Premenstrual Syndrome in Polish Adolescents-Results from POLKA 18 Youth-Led Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Cannabinoids and healthy ageing: the potential for extending healthspan and lifespan in preclinical models with an emphasis on Caenorhabditis elegans.GeroScience · 2024Review
- Assessment of frontal lobe functions in a sample of male cannabis users currently in abstinence: correlations with duration of use and their functional outcomes.Journal of cannabis research · 2024Article
- Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats.bioRxiv : the preprint server for biology · 2024Article
- The Developmental Trajectory to Cannabis Use Disorder.The American journal of psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Cannabis consumption during adolescence is an area of particular concern, owing to changes in the social and political perception of the drug, and presents a scientific, medical, and economic challenge. Major social and economic interests continue to push toward cannabis legalization as well as pharmaceutical development. As a result, shifting perceptions of both legal and illicit cannabis use across the population have changed the collective evaluation of the potential dangers of the product. The wave of cannabis legalization therefore comes with new responsibility to educate the public on potential risks and known dangers associated with both recreational and medical cannabis. Among these is the risk of long-term cognitive and psychological consequences, particularly following early-life initiation of use, compounded by high-potency and/or synthetic cannabis, and heavy/frequent use of the drug. Underlying these cognitive and psychiatric consequences are lasting aberrations in the development of synaptic function, often secondary to epigenetic changes. Additional factors such as genetic risk and environmental influences or nondrug toxic insults during development are also profound contributors to these long-term functional alterations following adolescent cannabis use. Preclinical studies indicate that exposure to cannabinoids during specific windows of vulnerability (e.g., adolescence) impacts neurodevelopmental processes and behavior by durably changing dendritic structure and synaptic functions, including those normally mediated by endogenous cannabinoids and neuronal circuits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.