Evidence map›Paper›PMID 36301459›Full record

ArticleVirus genes2023

Identification and genomic characterization of a novel HIV-1 unique recombinant form (CRF01_AE/CRF07_BC) in Zhejiang Province, China.

Qin Fan, Jing Liu, Chengliang Chai, Shuying Zhu, Qionglou Fang, Zhihong Guo, Yan Xia, Xiaobei Ding, Jiafeng Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qin FanDepartment of HIV/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, No.3399, Binsheng Road, Hangzhou, 310051, People's Republic of China.
Jing LiuSchool of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, 325035, People's Republic of China.
Chengliang ChaiDepartment of HIV/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, No.3399, Binsheng Road, Hangzhou, 310051, People's Republic of China.
Shuying ZhuDepartment of Microbiological Analysis, Jinhua Municipal Center for Disease Control and Prevention, Jinhua, 321002, People's Republic of China.
Qionglou FangDepartment of Microbiological Analysis, Jinhua Municipal Center for Disease Control and Prevention, Jinhua, 321002, People's Republic of China.
Zhihong GuoDepartment of HIV/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, No.3399, Binsheng Road, Hangzhou, 310051, People's Republic of China.
Yan XiaDepartment of HIV/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, No.3399, Binsheng Road, Hangzhou, 310051, People's Republic of China.
Xiaobei DingDepartment of HIV/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, No.3399, Binsheng Road, Hangzhou, 310051, People's Republic of China.
Jiafeng ZhangDepartment of HIV/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, No.3399, Binsheng Road, Hangzhou, 310051, People's Republic of China. jfzhang@cdc.zj.cn.

Funding

Basic Public Welfare Research Program of Zhejiang Province LGF20H260002Zhejiang Provincial Medicine and Health Science and Technology Plan 2022PY047
6 · The paper itself

Abstract

Mutation and recombination are important mechanisms leading to the frequent evolution and genetic diversity of viruses as HIV-1. In this study, we identified the near full-length genomic characterization of a novel HIV-1 unique recombinant form (URF) strain (Sample ID: ZJ20202195/ZJ/CHN/2020, hereafter referred to as ZJ20202195) isolated during the HIV-1 molecular surveillance in 2020 in Zhejiang Province, China, through different recombination analysis tools and phylogenetic analysis. Our results amply proved that the near full-length genome (NFLG) sequence of ZJ20202195 was a novel HIV-1 unique recombinant form (URF) consisting of CRF01_AE and CRF07_BC subtype, and delimited three recombinant segments, of which the Segment I (HXB2:776-5559 nucleotide (nt)) and Segment III (HXB2:6224-9412 nt) were mainly originated from CRF01_AE cluster g4a strains prevalent in China and Segment II (HXB2:5560-6223 nt) was from CRF07_BC subtype. Overall, our findings provide insight and a scientific basis in the genetic diversity and accurate determination of HIV-1 recombinant strains in China.

Indexed as

HIV-1HIV InfectionsChinaGenome, ViralGenomicsGenotypeHumansPhylogenyRecombination, GeneticSequence Analysis, DNAHIV-1Near full-length genome (NFLG)RecombinantUnique recombinant form (URF)

Identifiers

PMID36301459
PMCPMC9832081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.