ArticleTurkish journal of anaesthesiology and reanimation2022
Pregabalin Versus Duloxetine on Postoperative Analgesic Requirement Following Lower Extremity Trauma Surgeries: A randomised, Clinical Trial.
Article in Turkish journal of anaesthesiology and reanimation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Perioperative Use of Pregabalin vs. Duloxetine for Pain Management of Knee Fracture Surgery: A Double-Blind Randomized Clinical Trial.Iranian journal of pharmaceutical research : IJPRArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe use of pregabalin versus duloxetine in postoperative lower limb traumatic pain has not been compared. The aim of this study was to evaluate the response rate of rescue analgesic requirement with perioperative pregabalin versus duloxetine in lower limb trauma surgeries.
methodsIn this randomised, clinical trial, 60 patients of American Society of Anesthesiologists physical status I-II undergoing lower limb trauma surgery were randomised to receive oral pregabalin 150 mg day-1 or duloxetine 60 mg day-1, 2 hours prior to surgery and then once daily for next 2 days postoperatively. The surgery was performed under standardised spinal anaesthesia technique. The investigator was blinded to the study drug, oral paracetamol 1 g every 6 hours and intravenous diclofenac 75 mg was a rescue analgesic. The primary outcome of the study was response rate in terms of rescue analgesia requirement. Secondary outcomes included total rescue analgesia, visual analogue scale at rest and on movement, haemodynamics, anxiety depression score, and patient satisfaction score and adverse effects.
resultsIn group pregabalin, 60% of patients required the first dose of rescue analgesia versus 50% in group duloxetine for 72 hours postoperatively. In group pregabalin, 6.6% of patients required the second dose of rescue analgesia after a mean duration of 24 hours, and 10% of patients in group duloxetine required the second dose after a mean duration of 40 hours. The visual analogue scale scores, time to first rescue, and cumulative rescue analgesic were comparable in both the groups.
conclusionEquivalent rate-responsive rescue analgesia was required in patients receiving pregabalin or duloxetine following lower limb trauma surgery.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.