Evidence map›Paper›PMID 36301194›Full record

ArticleAllergy2023

Biomarkers of asthma relapse and lung function decline in adults with spontaneous asthma remission: A population-based cohort study.

Daniel J Tan, Caroline J Lodge, Eugene Haydn Walters, Adrian J Lowe, Dinh S Bui, Gayan Bowatte, Rangi Kandane-Rathnayake, Fahad M Aldakheel, Bircan Erbas, Garun S Hamilton and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daniel J TanAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Caroline J LodgeAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-2342-3888
Eugene Haydn WaltersAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Adrian J LoweAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-4691-8162
Dinh S BuiAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Gayan BowatteAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Rangi Kandane-RathnayakeSchool of Clinical Sciences, Monash University, Melbourne, Victoria, Australia.
Fahad M AldakheelDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Bircan ErbasSchool of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia.
Garun S HamiltonSchool of Clinical Sciences, Monash University, Melbourne, Victoria, Australia.
Paul S ThomasPrince of Wales' Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Mark HewSchool of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-7498-0000
Mimi L K TangMurdoch Children's Research Institute, Melbourne, Victoria, Australia.ORCID 0000-0002-3839-5293
Michael J AbramsonSchool of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Jennifer L PerretAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Shyamali C DharmageAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-6063-1937

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe extent to which biomarkers of asthma activity persist in spontaneous asthma remission and whether such markers are associated with future respiratory outcomes remained unclear. We investigated the association between sub-clinical inflammation in adults with spontaneous asthma remission and future asthma relapse and lung function decline.

methodsThe Tasmanian Longitudinal Health Study is a population-based cohort (n = 8583). Biomarkers of systemic inflammation were measured on participants at age 45, and latent profile analysis was used to identify cytokine profiles. Bronchial hyperresponsiveness (BHR) and nitric oxide products in exhaled breath condensate (EBC NOx) were measured at age 50. Participants with spontaneous asthma remission at ages 45 (n = 466) and 50 (n = 318) were re-evaluated at age 53, and associations between baseline inflammatory biomarkers and subsequent asthma relapse and lung function decline were assessed.

resultsWe identified three cytokine profiles in adults with spontaneous asthma remission: average (34%), Th2-high (42%) and Th2-low (24%). Compared to the average profile, a Th2-high profile was associated with accelerated decline in post-BD FEV

conclusionBHR and serum inflammatory cytokines have prognostic value in adults with spontaneous asthma remission. At-risk individuals with BHR, Th2-high or Th2-low cytokine profiles may benefit from closer monitoring and on-going follow-up.

Indexed as

AsthmaBronchial HyperreactivityAdultBiomarkersChronic DiseaseCohort StudiesHumansInflammationLungMiddle AgedNitric OxideRemission, SpontaneousBiomarkersNitric Oxideasthmabiomarkersendotypesprecision medicine

Identifiers

PMID36301194
PMCPMC10953440

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.