Evidence map›Paper›PMID 36301109›Full record

ArticleMicrobiology resource announcements2022

Complex Genomic Rearrangements following Selection in a Glutamine-Limited Medium over Hundreds of Generations.

Pieter Spealman, Grace Avecilla, Julia Matthews, Ina Suresh, David Gresham

Abstract read
In one paragraph

Article in Microbiology resource announcements, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pieter SpealmanCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, New York, USA.ORCID 0000-0002-7105-284X
Grace AvecillaCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, New York, USA.
Julia MatthewsCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, New York, USA.
Ina SureshCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, New York, USA.
David GreshamCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, New York, USA.ORCID 0000-0002-4028-0364

Funding

Regulation of Quiescence in Eukaryotic CellsR01GM107466 · NIGMS · NEW YORK UNIVERSITY · PI GRESHAM, DAVID · 2013 to 2022
$3.0M
Constraints and Consequences of Copy Number VariationR01GM134066 · NIGMS · NEW YORK UNIVERSITY · PI GRESHAM, DAVID · 2020 to 2023
$1.2M
The adaptive potential of translational regulationF32GM131573 · NIGMS · NEW YORK UNIVERSITY · PI SPEALMAN, PIETER · 2019 to 2021
$144k
NIGMS NIH HHS F32 GM131573NIGMS NIH HHS R01 GM107466NIGMS NIH HHS R01 GM134066NIH HHS F32-GM131573NIH HHS R01-GM107466NIH HHS R01-GM134066NSF DGE1342536NSF MCB-1818234
6 · The paper itself

Abstract

Large-scale genomic changes, including copy number variations (CNVs), are frequently observed in long-term evolution experiments (LTEEs). We have previously reported the detection of recurrent CNVs in Saccharomyces cerevisiae populations adapting to glutamine-limited conditions over hundreds of generations. Here, we present the whole-genome sequencing (WGS) assemblies of 7 LTEE strains and their ancestor.

Identifiers

PMID36301109
PMCPMC9670979

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.