Evidence map›Paper›PMID 36300902›Full record

ArticleThe Journal of organic chemistry2022

Conformationally Locked Carbocyclic Nucleosides Built on a 4'-Hydroxymethyl-3'-hydroxybicyclo[4.1.0]heptane Template. Stereoselective Synthesis and Antiviral Activity.

Sergio Jurado, Ona Illa, Angel Álvarez-Larena, Christophe Pannecouque, Félix Busqué, Ramon Alibés

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sergio JuradoDepartament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona 08193, Spain.
Ona IllaDepartament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona 08193, Spain.ORCID 0000-0001-7390-4893
Angel Álvarez-LarenaServei de Difracció de Raigs X, Universitat Autònoma de Barcelona, Bellaterra, Barcelona 08193, Spain.
Christophe PannecouqueDepartment of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49, Leuven B-3000, Belgium.
Félix BusquéDepartament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona 08193, Spain.
Ramon AlibésDepartament de Química, Universitat Autònoma de Barcelona, Bellaterra, Barcelona 08193, Spain.ORCID 0000-0002-7997-2691

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two new families of enantiomerically pure carbocyclic nucleoside analogues based on a cyclohexane moiety with five chiral centers and a fused cyclopropyl ring have been synthesized. A highly regio- and stereoselective synthetic approach for the modular construction of the functionalized bicyclo[4.1.0]heptyl azide intermediate

Indexed as

HeptanesNucleosidesAntiviral AgentsStereoisomerismTriazolesAntiviral AgentsHeptanesNucleosidesTriazoles

Identifiers

PMID36300902
PMCPMC9680032

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.