ReviewJournal of medical primatology2023
Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis).
Review in Journal of medical primatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Skeletal and body composition effects of orchiectomy in a colony of diet-induced obese cynomolgus macaques.JBMR plus · 2026Article
- In-Life Testicular Volume as an Indicator of Histological Testicular Development Suitable for Testicular Toxicity Evaluation in Male Cynomolgus Macaques (Animals : an open access journal from MDPI · 2026Article
- Age- and sex- related patterns in hematobiochemical and anthropometric parameters of Macaca monkeys.GeroScience · 2026Article
- TEDD 2.0: an advanced temporal gene expression database enabled by in-silico functional analyses for developmental mechanism investigation.Science China. Life sciences · 2026Article
- Histological characterization of major internal organs in infant common marmosets (Callithrix jacchus).PloS one · 2026Article
- Trends of laboratory nonhuman primate licensing in China between 2020 and 2024: A national database analysis.PloS one · 2026Article
- Comparative analysis of gut microbiota and host phenotypic characteristics across enterotype-like clusters in cynomolgus and rhesus macaques.Frontiers in microbiology · 2026Article
- Pharmacokinetics, Excretion, and Organ Distribution of the Novel Gadolinium-Based MRI Contrast Agent Gadoquatrane in Female Cynomolgus Monkeys.Investigative radiology · 2025Article
- Coagulation Hemostasis Parameters in Macaque Monkeys (Macaca spp.).Bulletin of experimental biology and medicine · 2025Article
- An orally available 4Journal of virology · 2025Article
- Intravenous Sodium Iodate Administration Induces Macula-Specific RPE Damage and Rod-Dominant Apoptosis in the Cynomolgus Monkey.Investigative ophthalmology & visual science · 2025Article
- Non-human primate: the new frontier model of female reproductive engineering.Frontiers in bioengineering and biotechnology · 2025Review
- Macular white dot lesions with hyperreflective optical coherence tomography findings in cynomolgus and rhesus monkeys.Molecular vision · 2024Article
- Differential effects of western versus mediterranean diets and psychosocial stress on ovarian function in female monkeys (Macaca fascicularis).Psychoneuroendocrinology · 2023Article
- Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis).Journal of medical primatology · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cynomolgus macaque has become the most used non-human primate species in nonclinical safety assessment during the past decades.
methodsThis review summarizes the biological data and organ system development milestones of the cynomolgus macaque available in the literature.
resultsThe cynomolgus macaque is born precocious relative to humans in some organ systems (e.g., nervous, skeletal, respiratory, and gastrointestinal). Organ systems develop, refine, and expand at different rates after birth. In general, the respiratory, gastrointestinal, renal, and hematopoietic systems mature at approximately 3 years of age. The female reproductive, cardiovascular and hepatobiliary systems mature at approximately 4 years of age. The central nervous, skeletal, immune, male reproductive, and endocrine systems complete their development at approximately 5 to 9 years of age.
conclusionsThe cynomolgus macaque has no meaningful developmental differences in critical organ systems between 2 and 3 years of age for use in nonclinical safety assessment.
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