ArticleMagnetic resonance in medicine2023
High frame rate deformation analysis of knee cartilage by spiral dualMRI and relaxation mapping.
Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Early Imaging Biomarkers of Cartilage Strain After ACL Reconstruction Predict Patient Pain and Altered Knee Loading.Annals of biomedical engineering · 2026Article
- An in silico mechanoregulatory model of depth-dependent adaptations to mechanical loading in intact and damaged cartilage: a proof of concept study.Biomechanics and modeling in mechanobiology · 2025Article
- Displacement-encoded MRI reveals biomechanical stiffening in rheumatoid arthritis wrists: a case control study.Scientific reports · 2025Article
- MRI-derived articular cartilage strains predict patient-reported outcomes six months post anterior cruciate ligament reconstruction.Scientific reports · 2025Article
- Multiscale correlations between joint and tissue-specific biomechanics and anatomy in postmortem ovine stifles.Scientific reports · 2025Article
- Magnetisation transfer, T1 and T2* relaxation in canine menisci of elderly dogs-anFrontiers in veterinary science · 2025Article
- Preliminary evaluation of full volume strain measurement in patellar cartilage following osteochondral allograft transplantation using magnetic resonance imaging.Frontiers in bioengineering and biotechnology · 2025Article
- Deep learning enables accurate soft tissue tendon deformation estimation in vivo via ultrasound imaging.Scientific reports · 2024Article
- Use of a novel magnetically actuated compression system to study the temporal dynamics of axial and lateral strain in human osteochondral plugs.Journal of biomechanics · 2024Article
- A method for defining tissue injury criteria reveals that ligament deformation thresholds are multimodal.Acta biomaterialia · 2023Article
- Multi-frame biomechanical and relaxometry analysis during in vivo loading of the human knee by spiral dualMRI and compressed sensing.Magnetic resonance in medicine · 2023Article
- Hyperelastic characterization reveals proteoglycans drive the nanoscale strain-stiffening response in hyaline cartilage.Journal of biomechanics · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeDaily activities including walking impose high-frequency cyclic forces on cartilage and repetitive compressive deformation. Analyzing cartilage deformation during walking would provide spatial maps of displacement and strain and enable viscoelastic characterization, which may serve as imaging biomarkers for early cartilage degeneration when the damage is still reversible. However, the time-dependent biomechanics of cartilage is not well described, and how defects in the joint impact the viscoelastic response is unclear.
methodsWe used spiral acquisition with displacement-encoding MRI to quantify displacement and strain maps at a high frame rate (25 frames/s) in tibiofemoral joints. We also employed relaxometry methods (T
resultsNormal and shear strains were concentrated on the bovine tibiofemoral contact area during loading, and the defected joint exhibited larger compressive strains. We also determined a positive correlation between the change of T
conclusionOur results indicate that spiral scanning with displacement encoding can quantitatively differentiate the damaged from intact joint using the strain and creep response. The viscoelastic response identified with this methodology could serve as biomarkers to detect defects in joints in vivo and facilitate the early diagnosis of joint diseases such as osteoarthritis.
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