Evidence map›Paper›PMID 36300763›Full record

ArticleAutophagy2023

Ablation of endothelial

Hongmin Yao, Jian Li, Zhixue Liu, Changhan Ouyang, Yu Qiu, Xiaoxu Zheng, Jing Mu, Zhonglin Xie

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 29 citations in OpenAlex.

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  19. A Novel tRNA-Derived Fragment, tRFInternational journal of molecular sciences · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Hongmin YaoCenter of Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia, USA.
Jian LiCenter of Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia, USA.
Zhixue LiuCenter of Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia, USA.
Changhan OuyangHubei Key Laboratory of Cardiovascular, Cerebrovascular and Metabolic Disorders, Hubei University of Science and Technology, Xianning, China.
Yu QiuCenter of Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia, USA.
Xiaoxu ZhengCenter of Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia, USA.
Jing MuCenter of Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia, USA.
Zhonglin XieCenter of Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia, USA.
Georgia State University · USHubei University of Science and Technology · CN

Funding

SNRK in ischemic vascular diseasesR01HL142287 · NHLBI · GEORGIA STATE UNIVERSITY · PI XIE, ZHONGLIN, ZOU, MING-HUI · 2018 to 2022
$3.0M
FUNDC1 and diabetic cardiomyopathyR01HL137371 · NHLBI · GEORGIA STATE UNIVERSITY · PI XIE, ZHONGLIN, ZOU, MING-HUI · 2017 to 2020
$2.8M
Autophagy and VSMC migrationR01HL132500 · NHLBI · GEORGIA STATE UNIVERSITY · PI XIE, ZHONGLIN, ZOU, MING-HUI · 2016 to 2019
$2.7M
Suppression of Autophagy-Dependent Clearance Mitochondria in Type 2 DiabetesR01HL128014 · NHLBI · GEORGIA STATE UNIVERSITY · PI XIE, ZHONGLIN, ZOU, MING-HUI · 2015 to 2018
$2.4M
NHLBI NIH HHS R01 HL128014NHLBI NIH HHS R01 HL132500NHLBI NIH HHS R01 HL137371NHLBI NIH HHS R01 HL142287
6 · The paper itself

Abstract

Ischemia-induced angiogenesis is critical for blood flow restoration and tissue regeneration, but the underlying molecular mechanism is not fully understood. ATG7 (autophagy related 7) is essential for classical degradative macroautophagy/autophagy and cell cycle regulation. However, whether and how ATG7 influences endothelial cell (EC) function and regulates post-ischemic angiogenesis remain unknown. Here, we showed that in mice subjected to femoral artery ligation, EC-specific deletion of

Indexed as

AutophagyFibroblastsAnimalsAutophagy-Related Protein 7DNA-Binding ProteinsHEK293 CellsHumansHuman Umbilical Vein Endothelial CellsHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitIschemiaKaryopherinsMiceSTAT1 Transcription FactorTranscription FactorsATG7 protein, humanAtg7 protein, mouseAutophagy-Related Protein 7DNA-Binding ProteinsHIF1A protein, humanHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitKaryopherinsSTAT1 protein, humanStat1 protein, mouseSTAT1 Transcription FactorTranscription FactorsZfp148 protein, mouseZNF148 protein, humanAngiogenesisATG7endothelial cellHIF1AischemiaSTAT1ZNF148/ZFP148/ZBP-89

Identifiers

PMID36300763
PMCPMC10240988
OpenAlexW4307430444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.