Evidence map›Paper›PMID 36300327›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023

Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease.

Stewart J Wiseman, Jun-Fang Zhang, Calum Gray, Charlene Hamid, Maria Del C Valdés Hernández, Lucia Ballerini, Michael J Thrippleton, Cameron Manning, Michael Stringer, Emilie Sleight and 11 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Retinal imaging for cerebrovascular risk stratification: evidence, limitations, and practical thresholds for the ophthalmologist.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 2 countries.

Stewart J WisemanCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-6739-5797
Jun-Fang ZhangDepartment of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Calum GrayEdinburgh Imaging Facilities, Edinburgh Imaging, University of Edinburgh, UK.ORCID 0000-0002-2816-4707
Charlene HamidCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Maria Del C Valdés HernándezCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Lucia BalleriniCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Michael J ThrippletonCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Cameron ManningCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Michael StringerCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-3811-4439
Emilie SleightCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Susana Muñoz ManiegaCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Alasdair MorganCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Yajun ChengCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Carmen ArteagaCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-2424-7123
Dany Jaime GarciaCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Una ClancyCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Fergus N DoubalCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Baljean DhillonCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Tom MacGillivrayCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Yun-Cheng WuDepartment of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Joanna M WardlawCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9812-6642
University of Edinburgh · GBUK Dementia Research Institute · GBShanghai Jiao Tong University · CNNHS Lothian · GBSichuan University · CN

Funding

British Heart FoundationMedical Research Council MC_PC_MR/S022880/1Medical Research Council MR/R01566X/1Wellcome TrustWellcome Trust 104916/Z/14/Z
6 · The paper itself

Abstract

Cerebral small vessel disease (SVD) is a cause of stroke and dementia. Retinal capillary microvessels revealed by optical coherence tomography angiography (OCTA) are developmentally related to brain microvessels. We quantified retinal vessel density (VD) and branching complexity, investigating relationships with SVD lesions, white matter integrity on diffusion tensor imaging (DTI) and cerebrovascular reactivity (CVR) to CO

Indexed as

Cerebral Small Vessel DiseasesStrokeWhite MatterAgedDiffusion Tensor ImagingHumansMagnetic Resonance ImagingMicrovesselscapillary branchingcerebrovascular reactivityOCTAperivascular spacesvessel density

Identifiers

PMID36300327
PMCPMC9903216
OpenAlexW4307356452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.