Evidence map›Paper›PMID 36300013›Full record

ArticleBeilstein journal of organic chemistry2022

Oxa-Michael-initiated cascade reactions of levoglucosenone.

Julian Klepp, Thomas Bousfield, Hugh Cummins, Sarah V A-M Legendre, Jason E Camp, Ben W Greatrex

Abstract read
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In one paragraph

Article in Beilstein journal of organic chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julian KleppSchool of Rural Medicine, University of New England, Armidale, NSW, 2351, Australia.
Thomas BousfieldDepartment of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, United Kingdom.
Hugh CumminsSchool of Rural Medicine, University of New England, Armidale, NSW, 2351, Australia.
Sarah V A-M LegendreSchool of Rural Medicine, University of New England, Armidale, NSW, 2351, Australia.
Jason E CampDepartment of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, United Kingdom.
Ben W GreatrexSchool of Rural Medicine, University of New England, Armidale, NSW, 2351, Australia.ORCID https://orcid.org/0000-0002-0356-4966

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reactions of aromatic aldehydes and levoglucosenone promoted by methoxide gives bridged α,β-unsaturated ketones, formed by a series of oxa-Michael-initiated cascade reactions in yields of up to 91% (14 examples). A complex series of equilibria operate during the reaction, and the formation of the bridged species is thermodynamically favored, except in the case of 5-methylfurfural and pyrrole-2-carboxaldehyde. This is the first report detailing this type of aldol/Michael cascade involving oxa-Michael initiation.

Indexed as

cascade reactionsgreen chemistrylevoglucosenoneoxa-Michael reaction

Identifiers

PMID36300013
PMCPMC9577383

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.