ArticleFrontiers in nutrition2022
Relationship between dietary selenium intake and serum thyroid function measures in U.S. adults: Data from NHANES 2007-2012.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 20 citations in OpenAlex.
- Free and Total Thyroxine Levels are Associated with Cardiovascular-Kidney-Metabolic Syndrome Stages in Elderly Cohorts from China and the United States: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- A Comprehensive Review of Selenium as a Key Regulator in Thyroid Health.Biological trace element research · 2025Review
- Unraveling the Link: Mendelian Randomization Reveals Causal Relationship Between Selenium and Metabolic Syndrome.Biological trace element research · 2025Article
- Association between the newly proposed dietary index for gut microbiota and thyroid function: NHANES 2007-2012.Frontiers in nutrition · 2025Article
- Relationship between vitamin B6 intake and thyroid function in US adults: NHANES 2007-2012 results.PloS one · 2025Article
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and serum thyroid function measures: Recent Findings from NHANES 2007-2012 and Mendelian randomization.Frontiers in endocrinology · 2025Article
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- Association of circulating minerals and vitamins with pregnancy complications: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- Impact of dietary selenium and blood concentration on liver function: a population-based study.Frontiers in nutrition · 2024Article
- Association between vitamin C intake and thyroid function among U.S. adults: a population-based study.Frontiers in endocrinology · 2024Article
- Interaction Between Dietary Selenium and Zinc Intakes on Hypothyroidism.Biological trace element research · 2023Article
- Associations of sleeping, sedentary and physical activity with phenotypic age acceleration: a cross-sectional isotemporal substitution model.BMC geriatrics · 2023Article
- Selenium, Iodine and Iron-Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism.International journal of molecular sciences · 2023Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although numerous studies have explored the relationship between selenium intake and thyroid diseases, few epidemiological studies have investigated the association between selenium intake and thyroid hormones. Therefore, we conducted this analysis to investigate the association between dietary selenium intake and thyroid hormones. Our sample included 5,575 adults (age ≥ 20) years from the National Health and Nutrition Examination Survey (NHANES) 2007-2012. Thyroid hormones, including total triiodothyronine (T3), total thyroxine (T4), free T3 (FT3), free T4 (FT4), and thyroid-stimulating hormone (TSH), were detected. Multivariable linear regression models showed that log10-transformed selenium intake (LogSe) was negatively correlated with TT4 (β = -0.383, 95% CI: -0.695, -0.070) and TT4/TT3 (β = -0.003, 95% CI: -0.006, -0.0004) in U.S. adults. Besides, additional stratified analyses by sex demonstrated that LogSe was negatively associated with TT4 (β = -0.007, 95% CI: -0.013, -0.001) and TT4/TT3 (β = -0.664, 95% CI: -1.182, -0.146) and positively associated with FT4/TT4 (β = 0.031, 95% CI: 0.004, 0.059) in male adults. Meanwhile, subgroup analysis by iodine status showed that LogSe was negatively associated with TT4 (β = -0.006, 95% CI: -0.011, -0.002), FT4/FT3 (β = -0.011, 95% CI: -0.023, -0.00002) and TT4/TT3 (β = -0.456, 95% CI: -0.886, -0.026) in iodine sufficiency but not in iodine deficiency adults. Our results demonstrated that the increased dietary selenium intake was negatively correlated with TT4 and TT4/TT3 in U.S. adults. Furthermore, the association between dietary selenium intake and thyroid hormones was more pronounced in males and iodine sufficiency adults.
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