ArticleFrontiers in nutrition2022
The association between caffeine intake and risk of kidney stones: A population-based study.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Lifestyle factors, serum parameters, metabolic comorbidities, and the risk of kidney stones: a Mendelian randomization study.Frontiers in endocrinology · 2023Pooled it
- Assessing Risk of Nephrolithiasis in Urology Residents: Are We Practicing What We Preach?Cureus · 2026Article
- Article
- The effects of immune cells and blood metabolites on kidney stones: a bidirectional two-sample Mendelian randomization study and mediation analysis.International urology and nephrology · 2025Article
- Review
- Novel Insights Into the Causal Association Between Dietary Factors and Risk of Urinary Calculus: A Multivariate and Two-Step Mendelian Randomization Analysis.Food science & nutrition · 2025Article
- A study on the relationship between the weight-adjusted waist index and kidney stone prevalence mediated by diabetes: data from NHANES 2007-2018.Scientific reports · 2025Article
- Balancing Stone Prevention and Kidney Function: A Therapeutic Dilemma.Journal of clinical medicine · 2025Review
- Identification of the relationship between 1400 blood metabolites and urolithiasis: A bidirectional Mendelian randomization study.Medicine · 2025Article
- National analysis of the dietary index for gut microbiota and kidney stones: evidence from NHANES (2007-2018).Frontiers in nutrition · 2025Article
- Exploring the association between dietary caffeine and chronic musculoskeletal pain: a cross-sectional analysis of NHANES.Frontiers in nutrition · 2025Article
- Threshold effects between caffeine intake and urine flow rate: a population-based cross-sectional study.International urology and nephrology · 2024Article
- Oxalates: Dietary Oxalates and Kidney Inflammation: A Literature Review.Integrative medicine (Encinitas, Calif.) · 2024Review
- Article
- Caffeine causes cell cycle arrest at G0/G1 and increases of ubiquitinated proteins, ATP and mitochondrial membrane potential in renal cells.Computational and structural biotechnology journal · 2023Article
- Coffee and caffeine intake and depression in postpartum women: A cross-sectional study from the National Health and Nutrition Examination Survey 2007-2018.Frontiers in psychology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although many studies have proven the beneficial effects of caffeine on human health, the association between caffeine intake and the risk of kidney stones is limited in large epidemiologic studies. Objectives: We aimed to investigate the association between caffeine intake and the risk of kidney stones. Methods: A total of 30,716 participants (with weight numbers of 204, 189, and 886) with a history of kidney stone were included in this analysis. All data were survey-weighted, and corresponding logistic regression models were performed to examine the associations between caffeine intake and the risk of kidney stones. Results: In a fully adjusted model, a per-quartile increase in caffeine intake was associated with a 5.32% decreased risk of kidney stones. In the subgroup analysis, the multivariate-adjusted odds ratios (95% confidence intervals) of the risk of kidney stones for per-quartile increments in caffeine intake were 0.9650 (0.9643, 0.9656) for men, 0.9320 (0.9313, 0.9327) for women, 0.9384 (0.9378, 0.9389) for white race individuals, 1.0281 (1.0270, 1.0292) for nonwhite race individuals, 0.9460 (0.9455, 0.9465) for overweight/obese individuals, and 0.9314 (0.9303, 0.9324) for non-overweight individuals, 0.9100 (0.9094, 0.9105) for caffeine from coffee, and 1.0021 (1.0013, 1.0029) for caffeine from non-coffee sources. Conclusion: Caffeine intake was negatively associated with the risk of kidney stones. In subgroup analyses, the negative association of caffeine with kidney stone risk was only found in white individuals. In addition, the decreased risk was found higher in women and non-overweight individuals. Especially for women, white individuals and non-overweight individuals. The protective effect of caffeine intake from coffee on stone formation was more significant than that of caffeine from non-coffee sources.
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