Evidence map›Paper›PMID 36299737›Full record

ArticleArXiv2022

Emerging dominant SARS-CoV-2 variants.

Jiahui Chen, Rui Wang, Yuta Hozumi, Gengzhuo Liu, Yuchi Qiu, Xiaoqi Wei, Guo-Wei Wei

Abstract readPreprint
In one paragraph

Article in ArXiv, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Automatic detection of spinal pathologies based on MRI scans.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jiahui ChenDepartment of Mathematics, Michigan State University, MI 48824, USA.
Rui WangDepartment of Mathematics, Michigan State University, MI 48824, USA.
Yuta HozumiDepartment of Mathematics, Michigan State University, MI 48824, USA.
Gengzhuo LiuDepartment of Mathematics, Michigan State University, MI 48824, USA.
Yuchi QiuDepartment of Mathematics, Michigan State University, MI 48824, USA.
Xiaoqi WeiDepartment of Mathematics, Michigan State University, MI 48824, USA.
Guo-Wei WeiDepartment of Mathematics, Michigan State University, MI 48824, USA.

Funding

AI-based platform for predicting emerging vaccine-escape variants and designing mutation-proof antibodiesR01AI164266 · NIAID · UNIVERSITY OF GEORGIA · PI Guowei Wei, YONG-HUI ZHENG · 2022 to 2026
$2.7M
Synergistic integration of topology and machine learning for the predictions of protein-ligand binding affinities and mutation impactsR01GM126189 · NIGMS · MICHIGAN STATE UNIVERSITY · PI WEI, GUOWEI · 2018 to 2021
$1.4M
NIAID NIH HHS R01 AI164266NIGMS NIH HHS R01 GM126189
6 · The paper itself

Abstract

Accurate and reliable forecasting of emerging dominant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants enables policymakers and vaccine makers to get prepared for future waves of infections. The last three waves of SARS-CoV-2 infections caused by dominant variants Omicron (BA.1), BA.2, and BA.4/BA.5 were accurately foretold by our artificial intelligence (AI) models built with biophysics, genotyping of viral genomes, experimental data, algebraic topology, and deep learning. Based on newly available experimental data, we analyzed the impacts of all possible viral spike (S) protein receptor-binding domain (RBD) mutations on the SARS-CoV-2 infectivity. Our analysis sheds light on viral evolutionary mechanisms, i.e., natural selection through infectivity strengthening and antibody resistance. We forecast that BA.2.10.4, BA.2.75, BQ.1.1, and particularly, BA.2.75+R346T, have high potential to become new dominant variants to drive the next surge.

Identifiers

PMID36299737
PMCPMC9603820

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.