Evidence map›Paper›PMID 36299620›Full record

ArticleTH open : companion journal to thrombosis and haemostasis2022

Extended Thromboprophylaxis in Hospitalized Patients with Heart Failure: A Post Hoc Analysis of the MAGELLAN Study.

Alex C Spyropoulos, Gary E Raskob, Theodore E Spiro, Wentao Lu, Yoriko De Sanctis, John Albanese, Alexandre Mebazaa, Elliot S Barnathan

Open access · goldAbstract read
In one paragraph

Article in TH open : companion journal to thrombosis and haemostasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Alex C SpyropoulosDepartment of Medicine, The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, The Feinstein Institute for Medical Research, Manhasset, New York, United States.ORCID 0000-0002-3175-461X
Gary E RaskobHudson College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
Theodore E SpiroClinical Development, Pharmaceuticals, Bayer US LLC, Whippany, New Jersey, United States.
Wentao LuJanssen Research & Development, LLC, Raritan, New Jersey, United States.
Yoriko De SanctisClinical Development, Pharmaceuticals, Bayer US LLC, Whippany, New Jersey, United States.
John AlbaneseJanssen Research & Development, LLC, Raritan, New Jersey, United States.
Alexandre MebazaaDepartment of Anesthesia and Critical Care, University of Paris, Paris, France.
Elliot S BarnathanJanssen Research & Development, LLC, Raritan, New Jersey, United States.ORCID 0000-0001-7744-1486
Janssen (United States) · USBayer (United States) · USNorthwell Health · USUniversité Paris Cité · FRUniversity of Oklahoma Health Sciences Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This post hoc subgroup analysis examined efficacy and safety outcomes with extended thromboprophylaxis rivaroxaban compared with in-hospital enoxaparin in 2,078 patients from the MAGELLAN study who had a hospitalization for heart failure or a history of heart failure and a lower risk of bleeding. A significant 36% reduction in the composite endpoint of asymptomatic proximal deep vein thrombosis (DVT) in the lower extremity, symptomatic DVT in the lower extremity (proximal or distal), symptomatic nonfatal pulmonary embolism, and venous thromboembolism-related death was observed with rivaroxaban. Major bleeding was low in both groups and not significantly increased with rivaroxaban.

Indexed as

direct oral anticoagulantsheart failuremedically illrivaroxabanthrombosisvenous thromboembolism

Identifiers

PMID36299620
PMCPMC9546607
OpenAlexW4292342677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.