Evidence map›Paper›PMID 36299556›Full record

ArticleSouthern African journal of HIV medicine2022

Rifampicin resistance and mortality in patients hospitalised with HIV-associated tuberculosis.

Ruan Spies, Charlotte Schutz, Amy Ward, Avuyonke Balfour, Muki Shey, Mark Nicol, Rosie Burton, Bianca Sossen, Robert Wilkinson, David Barr and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Southern African journal of HIV medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Ruan SpiesDepartment of Medicine, New Somerset Hospital, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-1584-9141
Charlotte SchutzDepartment of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0001-8329-6158
Amy WardDepartment of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-7725-6763
Avuyonke BalfourWellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa) and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-3006-449X
Muki SheyDepartment of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-8776-4737
Mark NicolDivision of Infection and Immunity, School of Biomedical Sciences, University of Western Australia, Perth, Australia.ORCID https://orcid.org/0000-0002-1366-4805
Rosie BurtonMédecins sans Frontières, Cape Town, South Africa.ORCID https://orcid.org/0000-0003-1217-8191
Bianca SossenDepartment of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-6028-3351
Robert WilkinsonWellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa) and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-2753-1800
David BarrWellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa) and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-2922-9381
Graeme MeintjesDepartment of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0003-1196-4414
University of Cape Town · ZAMédecins Sans Frontières · ZASomerset Hospital · ZAThe University of Western Australia · AUUniversity of Liverpool · GB

Funding

Inflammatory determinants of disease severity and treatment outcome in TB patientsU01AI115940 · NIAID · UNIVERSITY OF CAPE TOWN · PI SHER, ALAN, WILKINSON, ROBERT JOHN · 2015 to 2019
$1.1M
NIAID NIH HHS U01 AI115940Wellcome Trust 211360/Z/18/Z
6 · The paper itself

Abstract

Background: Patients with HIV and drug-resistant tuberculosis (TB) are at high risk of death. Objectives: We investigated the association between rifampicin-resistant TB (RR-TB) and mortality in a cohort of patients who were admitted to hospital at the time of TB diagnosis. Method: Adults hospitalised at Khayelitsha Hospital and diagnosed with HIV-associated TB during admission, were enrolled between 2013 and 2016. Clinical, biochemical and microbiological data were prospectively collected and participants were followed up for 12 weeks. Results: Participants with microbiologically confirmed TB ( Conclusion: Mortality at 12 weeks in participants with RR-TB was high compared to participants with RS-TB. Delays in the initiation of appropriate treatment and poorer regimen efficacy are proposed as contributors to higher mortality in hospitalised patients with HIV and RR-TB.

Indexed as

drug-resistant tuberculosisHIV-associated tuberculosisKhayelitsha Hospitalmulti-drug resistant TBrifampicin-resistant tuberculosisTB

Identifiers

PMID36299556
PMCPMC9575347
OpenAlexW4298394261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.