ArticleFrontiers in psychiatry2022
Brain morphometric abnormalities and their associations with affective symptoms in males with methamphetamine use disorder during abstinence.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Modulatory Effects of Methadone on Brain Network Instability in Methamphetamine Use; A Cross-sectional Study.Archives of academic emergency medicine · 2026Article
- Altered morphological cortical thickness and disrupted network attributes and its relationships with drug use characteristics and impulsivity in abstinent male subjects with methamphetamine use disorder.Psychological medicine · 2025Article
- The Effects of Active Methamphetamine Use Disorder and Regular Sports Activities on Brain Volume in Adolescents.Journal of clinical medicine · 2025Article
- Mapping structural covariance networks of emotional withdrawal symptoms in males with methamphetamine use disorder during abstinence.Addiction biology · 2024Article
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Methamphetamine (METH) use induces neurotoxic effects in brain structures and affective symptoms that persist during abstinence. However, the brain morphometry of individuals with METH use disorder (MUD) remains unclear, as well as their associations with affective symptoms during abstinence. Methods: Forty-eight abstinent males with MUD and 66 age-, sex-, and education-matched healthy controls (HCs) underwent high-resolution T1-weighted magnetic resonance imaging. Cortical thickness, surface area, volume, local gyrification index (LGI), and subcortical volume were obtained with FreeSurfer software. Brain morphometry differences between groups and their associations with affective symptoms and drug abuse history within the males with MUD were examined, with intracranial volume, age, and years of education as covariates. Results: Compared with the HCs, the individuals with MUD showed a significantly higher LGI in the right cuneus gyrus, left lingual gyrus, bilateral supramarginal gyrus, right inferior parietal gyrus (IPG), and right dorsal anterior cingulate cortex (clusterwise Conclusion: Brain morphometric abnormalities in abstinent males with MUD were characterized by hypergyrification across multiple mid-posterior brain regions anda smaller volume of the left NAcc.Gyrification of the right IPG may be a potential neural substrate underlying the affective symptoms experienced by MUDs during abstinence.
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