Evidence map›Paper›PMID 36299435›Full record

ArticlemedRxiv : the preprint server for health sciences2022

Viral infectivity in pediatric SARS-CoV-2 clinical samples does not vary by age.

Madaline M Schmidt, Hannah W Despres, David J Shirley, Michael E Bose, Kate C McCaul, Jessica W Crothers, Kelly J Henrickson, Benjamin Lee, Emily A Bruce

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Madaline M SchmidtDepartment of Microbiology and Molecular Genetics, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington VT, 05405, USA.
Hannah W DespresDepartment of Microbiology and Molecular Genetics, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington VT, 05405, USA.
David J ShirleyFaraday, Inc. Data Science Department. Burlington VT, 05405, USA.
Michael E BoseDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee WI, 53226, USA.
Kate C McCaulDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee WI, 53226, USA.
Jessica W CrothersDepartment of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington VT, 05405, USA.
Kelly J HenricksonDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee WI, 53226, USA.
Benjamin LeeDepartment of Pediatrics, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington VT, 05405, USA.
Emily A BruceDepartment of Microbiology and Molecular Genetics, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington VT, 05405, USA.
University of Vermont · USMedical College of Wisconsin · USFaraday Technology (United States) · US

Funding

Vermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8M
NIGMS NIH HHS P30 GM118228
6 · The paper itself

Abstract

During the early months of the SARS-CoV-2 pandemic, notable uncertainty emerged regarding the role of children in transmission dynamics. With time, it became more clear that children were susceptible to infection with SARS-CoV-2, but that the vast majority of children experienced mild symptoms with lower incidence of severe disease. This pattern remained consistent despite the later emergence of SARS-CoV-2 variants, including Delta and Omicron, even among children <5 ineligible for vaccination. The relative lack of severe disease in the pediatric population raised questions regarding viral kinetics and infectivity in children versus adults. We hypothesized that unique virologic features in children could explain this apparent decrease in symptoms and transmissibility early in the pandemic.

Identifiers

PMID36299435
PMCPMC9603833
OpenAlexW4306752666

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.