Evidence map›Paper›PMID 36299432›Full record

ArticleResearch square2022

Gamma' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity.

Lucy Z Kornblith, Bindhya Sadhanandhan, Sreepriya Arun, Rebecca Long, Alicia J Johnson, Jamie Noll, C N Ramchand, John K Olynyk, David H Farrell

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Lucy Z KornblithUniversity of California.
Bindhya SadhanandhanTheragen Biologics Pvt Ltd.
Sreepriya ArunTheragen Biologics Pvt Ltd.
Rebecca LongFiona Stanley Fremantle Hospital Group, Murdoch, Western Australia, Australia and Edith Cowan University, Joondalup, Western Australia, Australia.
Alicia J JohnsonOregon Health & Science University.
Jamie NollGamma Diagnostics.
C N RamchandMagGenome Pvt Ltd.
John K OlynykFiona Stanley Fremantle Hospital Group, Murdoch, Western Australia, Australia and Edith Cowan University, Joondalup, Western Australia, Australia.
David H FarrellOregon Health & Science University.
Edith Cowan University · AUOregon Health & Science University · USTheragen · KRUniversity of California System · US

Funding

Post-Injury Platelet Biology: Mechanisms and OutcomesK23GM130892 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORNBLITH, LUCY ZUMWINKLE · 2018 to 2022
$995k
NIGMS NIH HHS K23 GM130892
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is characterized by a pro-inflammatory state associated with organ failure, thrombosis, and death. We investigated a novel inflammatory biomarker, γ' fibrinogen (GPF), in 103 hospitalized patients with COVID-19 and 19 healthy controls. We found significant associations between GPF levels and the severity of COVID-19 as judged by blood oxygen saturation (SpO

Identifiers

PMID36299432
PMCPMC9603834
OpenAlexW4307028146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.