ArticleERJ open research2022
Validation of the cough phenotype TBQ among elderly Finnish subjects.
Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The prevalence and risk factors of respiratory symptoms in Finland: a comparative analysis.European clinical respiratory journal · 2025Article
- Heritability of cough across two generations: the RHINESSA study.ERJ open research · 2024Article
- Cough Sensitivity to Several External Triggers is Associated with Multiple Non-respiratory Symptoms.Lung · 2023Article
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Authors and funding
4 authors.
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Abstract
Background: Phenotypes can be utilised in the clinical management of disorders. Approaches to phenotype disorders have evolved from subjective expert opinion to data-driven methodologies. A previous cluster analysis among working-age subjects with cough revealed a phenotype TBQ (triggers, background disorders, quality-of-life impairment), which included 38% of the subjects with cough. The present study was carried out to validate this phenotyping among elderly, retired subjects with cough. Methods: This was an observational cross-sectional study conducted Results: Two clusters were identified. Cluster A included 75.2% of the subjects and cluster B 24.8% of the subjects. The three most important variables to separate the clusters were the number of cough triggers (mean±sd 2.47±2.34 Conclusion: The phenotype TBQ could be identified also among elderly, retired subjects with cough, thus validating the previous phenotyping among working-age subjects. The main underlying pathophysiological feature separating the phenotype TBQ from the common cough phenotype is probably hypersensitivity of the cough reflex arc.
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