Evidence map›Paper›PMID 36299286›Full record

ReviewFrontiers in bioengineering and biotechnology2022

Strategies for the production of dsRNA biocontrols as alternatives to chemical pesticides.

James Hough, John D Howard, Stephen Brown, David E Portwood, Peter M Kilby, Mark J Dickman

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. EngineeredInsects · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Insects · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Harnessing double-stranded RNA (dsRNA): a sustainable approach to pest management.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

James HoughDepartment of Chemical and Biological Engineering, University of Sheffield, Sheffield, United Kingtom.
John D HowardDepartment of Chemical and Biological Engineering, University of Sheffield, Sheffield, United Kingtom.
Stephen BrownSheffield RNAi Screening Facility, School of Biosciences, University of Sheffield, Sheffield, United Kingtom.
David E PortwoodSyngenta, Jealott's Hill International Research Centre, Bracknell, United Kingdom.
Peter M KilbySyngenta, Jealott's Hill International Research Centre, Bracknell, United Kingdom.
Mark J DickmanDepartment of Chemical and Biological Engineering, University of Sheffield, Sheffield, United Kingtom.
University of Sheffield · GBSyngenta (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current crop pest control strategies rely on insecticidal and fungicidal sprays, plant genetic resistance, transgenes and agricultural practices. However, many insects, plant viruses, and fungi have no current means of control or have developed resistance against traditional pesticides. dsRNA is emerging as a novel sustainable method of plant protection as an alternative to traditional chemical pesticides. The successful commercialisation of dsRNA based biocontrols for effective pest management strategies requires the economical production of large quantities of dsRNA combined with suitable delivery methods to ensure RNAi efficacy against the target pest. A number of methods exist for the production and delivery of dsRNA based biocontrols and here we review alternative methods currently employed and emerging new approaches for their production. Additionally, we highlight potential challenges that will need to be addressed prior to widespread adoption of dsRNA biocontrols as novel sustainable alternatives to traditional chemical pesticides.

Indexed as

biopesticicdesdsRNApest managementRNAiRNAi pest control

Identifiers

PMID36299286
PMCPMC9588923
OpenAlexW4303958772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.